Division of Immunology, Department of Pathology, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.
Front Immunol. 2018 Feb 13;9:225. doi: 10.3389/fimmu.2018.00225. eCollection 2018.
One of the first steps toward mounting an effective immune response to (Mtb) is recognition of the pathogen through pattern-recognition receptors (PRRs) expressed by innate immune cells. Activation of the PRR Dectin-1 by an unknown mycobacterial ligand triggers an intracellular signaling cascade involving numerous proteins, including spleen tyrosine kinase, protein kinase C-delta, and caspase recruitment domain family member 9, some of which have been shown to influence host immune response to TB infection. Here, we review the role of Dectin-1 signaling pathway in anti-mycobacterial immunity and discuss its contribution in the control of Mtb infection, and potential applications in TB vaccine adjuvanticity.
对（Mtb）产生有效免疫反应的第一步之一是通过先天免疫细胞表达的模式识别受体（PRR）识别病原体。PRR Dectin-1 被未知的分枝杆菌配体激活，触发涉及许多蛋白质的细胞内信号级联反应，其中一些蛋白质已被证明会影响宿主对 TB 感染的免疫反应。在这里，我们回顾了 Dectin-1 信号通路在抗分枝杆菌免疫中的作用，并讨论了它在控制 Mtb 感染中的贡献以及在 TB 疫苗佐剂中的潜在应用。
