Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, South Africa.
Microbes Infect. 2011 Feb;13(2):198-201. doi: 10.1016/j.micinf.2010.10.013. Epub 2010 Oct 27.
There is interest in identifying the pattern recognition receptors involved in initiating protective or non-protective host responses to Mycobacterium tuberculosis (Mtb). Here we explored the role of the Syk/CARD9-coupled receptor, Dectin-1, using an aerosol model of Mtb infection in wild-type and Dectin-1 deficient mice. We observed a reduction in pulmonary bacilli burdens in the Dectin-1 deficient animals, but this did not correlate with significant changes in pulmonary pathology, cytokine levels or ability of these animals to survive the infection. Thus Dectin-1 makes a minor contribution to susceptibility to Mtb infections in mice.
人们对于鉴定与分枝杆菌（Mycobacterium tuberculosis，Mtb）引发保护或非保护宿主反应相关的模式识别受体很感兴趣。在此，我们利用分枝杆菌感染的气溶胶模型，在野生型和 Dectin-1 缺陷型小鼠中探索了 Syk/CARD9 偶联受体 Dectin-1 的作用。我们观察到 Dectin-1 缺陷型动物肺部细菌负荷减少，但这与肺部病理学、细胞因子水平或这些动物在感染中存活能力的显著变化无关。因此，Dectin-1 在小鼠对 Mtb 感染的易感性方面贡献较小。
