Marakalala Mohlopheni Jackson, Graham Lisa M, Brown Gordon D
Institute of Infectious Diseases and Molecular Medicine, Division of Immunology, CLS, University of Cape Town, Cape Town, South Africa.
Clin Dev Immunol. 2010;2010:567571. doi: 10.1155/2010/567571. Epub 2011 Jan 9.
There is increasing interest in understanding the mechanisms underlying the interactions that occur between Mycobacterium tuberculosis and host innate immune cells. These cells express pattern recognition receptors (PRRs) which recognise mycobacterial pathogen-associated molecular patterns (PAMPs) and which can influence the host immune response to the infection. Although many of the PRRs appear to be redundant in the control of M. tuberculosis infection in vivo, recent discoveries have revealed a key, nonredundant, role of the Syk/CARD9 signalling pathway in antimycobacterial immunity. Here we review these discoveries, as well as recent data investigating the role of the Syk/CARD9-coupled PRRs that have been implicated in mycobacterial recognition, including Dectin-1 and Mincle.
人们对了解结核分枝杆菌与宿主固有免疫细胞之间相互作用的潜在机制越来越感兴趣。这些细胞表达模式识别受体（PRR），其识别分枝杆菌病原体相关分子模式（PAMP），并可影响宿主对感染的免疫反应。尽管许多PRR在体内控制结核分枝杆菌感染方面似乎是多余的，但最近的发现揭示了Syk/CARD9信号通路在抗分枝杆菌免疫中的关键、非冗余作用。在此，我们综述这些发现以及最近关于Syk/CARD9偶联的PRR在分枝杆菌识别中作用的研究数据，这些PRR包括Dectin-1和Mincle。
