Department of Gynaecology and Reproductive Medicine and Center for Gynecologic Oncology, University Women's Hospital Jena, Jena University Hospital, Friedrich-Schiller-University Jena, Am Klinikum 1, 07747, Jena, Germany.
Skin and Laser Centre Landgrafen, Jena, Germany.
J Cancer Res Clin Oncol. 2018 May;144(5):955-960. doi: 10.1007/s00432-018-2614-8. Epub 2018 Feb 27.
First evaluation of dual-phase vaginal Er:YAG laser to omit hormonal treatment for atrophy-related symptoms in post-menopausal breast cancer survivors following prolapse surgery.
Patients with a history of breast cancer at the time of surgery for pelvic organ prolapse were offered non-hormonal vaginal Er:YAG laser treatment when complaining of atrophy-related genitourinary syndrome of menopause. A single 10-min course of dual-phase protocol of pulsed Er:YAG laser (2940 nm, fractional ablative and thermal mode, fluence according to tissue thickness). Follow-up included subjective satisfaction, vaginal pH, vaginal health index (VHI), and complications after 6 weeks.
A total of 16 breast cancer survivors (age 71 years, SD 7) had been seeking treatment for pelvic floor symptoms related to vaginal atrophy at follow-up visits after prolapse surgery. All ablative vaginal Er:YAG laser outpatient procedures were successfully completed, all patients returned to daily activities without a need for analgetic medication. Evaluation was performed after 8.3 (SD 2.5) weeks. Pre-laser VHI scored 16 (SD 4.6) and post-laser VHI 20 (SD 3) with p = 0.01. Patients were satisfied in 94% (n = 15) regarding symptom relief.
Breast cancer survivors with atrophy-related complaints after pelvic floor surgery may benefit from vaginal application of this innovative dual protocol of Er:YAG laser technology as a non-hormonal treatment approach.
首次评估双相阴道铒:YAG 激光治疗绝经后盆腔器官脱垂手术后因萎缩相关症状的乳腺癌幸存者,以避免激素治疗。
对于因脱垂手术而患有乳腺癌病史的患者,当抱怨与绝经期相关的泌尿生殖系统萎缩症状时,可提供非激素阴道铒:YAG 激光治疗。单次 10 分钟的双相脉冲铒:YAG 激光方案(2940nm,分束消融和热模式,根据组织厚度调整能量密度)。随访包括主观满意度、阴道 pH 值、阴道健康指数(VHI)和 6 周后的并发症。
共有 16 名乳腺癌幸存者(年龄 71 岁,标准差 7)在脱垂手术后因阴道萎缩相关盆底症状而在随访时寻求治疗。所有消融性阴道铒:YAG 激光门诊手术均成功完成,所有患者均无需使用镇痛药即可恢复日常活动。评估在激光治疗后 8.3(标准差 2.5)周进行。治疗前的 VHI 评分为 16(标准差 4.6),治疗后的 VHI 评分为 20(标准差 3),p=0.01。94%(n=15)的患者对症状缓解感到满意。
对于因盆腔底手术后出现萎缩相关症状的乳腺癌幸存者,这种创新的铒:YAG 激光双相方案阴道应用可能作为一种非激素治疗方法从中获益。