Treviño-Rangel Rogelio de J, Espinosa-Pérez José F, Villanueva-Lozano Hiram, Montoya Alexandra M, Andrade Angel, Bonifaz Alexandro, González Gloria M
Department of Microbiology, School of Medicine, Universidad Autónoma de Nuevo León, Av. Francisco I. Madero and Dr. Eduardo A. Pequeño, s/n. Mitras Centro, 64460, Monterrey, NL, Mexico.
Dermatology Service and Mycology Department, Hospital General de México "Dr. Eduardo Liceaga", Mexico City, Mexico.
Folia Microbiol (Praha). 2018 Jul;63(4):517-523. doi: 10.1007/s12223-018-0592-5. Epub 2018 Feb 27.
Candida bracarensis is an emerging cryptic species within the Candida glabrata clade. To date, little is known about its epidemiology, virulence, and antifungal susceptibility. This study documents the occurrence of C. bracarensis for the first time in Mexico and focuses on its in vitro production of hydrolytic enzymes, as well as antifungal susceptibility to echinocandins. This strain was isolated from a vaginal swab of a female with vulvovaginal candidosis; exhibited a very strong activity of aspartyl proteinase, phospholipase, and hemolysin; and was susceptible to caspofungin, anidulafungin, and micafungin (MIC = 0.031 μg/mL). Data obtained could contribute to the knowledge of the epidemiology and virulence attributes of this yeast as a fungal opportunistic human pathogen.
布拉加假丝酵母是光滑假丝酵母进化枝内一个新出现的隐性菌种。迄今为止，人们对其流行病学、毒力和抗真菌药敏性知之甚少。本研究首次记录了墨西哥布拉加假丝酵母的出现情况，并重点关注其水解酶的体外产生以及对棘白菌素的抗真菌药敏性。该菌株从一名患有外阴阴道念珠菌病的女性阴道拭子中分离得到；表现出非常强的天冬氨酸蛋白酶、磷脂酶和溶血素活性；并且对卡泊芬净、阿尼芬净和米卡芬净敏感（最低抑菌浓度 = 0.031μg/mL）。所获得的数据有助于了解这种酵母作为人类机会性真菌病原体的流行病学和毒力特性。
