抑制 Lats1/p-YAP1 通路减轻创伤性脑损伤大鼠模型中的神经元凋亡和神经功能缺损。
Inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of traumatic brain injury.
机构信息
Department of Neurosurgery and Translational Medicine Center, The First People's Hospital of Zhangjiagang, Soochow University, Suzhou, China.
Department of Neurosurgery, Zhangjiagang Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Suzhou, China.
出版信息
CNS Neurosci Ther. 2018 Oct;24(10):906-916. doi: 10.1111/cns.12833. Epub 2018 Feb 27.
Abstract
AIMS
To investigate the roles of Lats1/p-YAP1 pathway in TBI-induced neuronal apoptosis and neurological deficits in rats.
RESULTS
We found that Lats1 and YAP1 were expressed in cerebral cortex neurons of Sprague-Dawley rats, and the phosphorylation levels of Lats1 and YAP1 in injured regions were significantly increased after TBI. Furthermore, inhibition of Lats1 not only decreased the level of p-YAP1, but also attenuated neuronal apoptosis and neurological impairment.
CONCLUSIONS
Our work demonstrates that inhibition of Lats1/p-YAP1 pathway mitigates neuronal apoptosis and neurological deficits in a rat model of TBI.
摘要
目的
研究 Lats1/p-YAP1 通路在创伤性脑损伤（TBI）诱导的大鼠神经元凋亡和神经功能缺损中的作用。
结果
我们发现 Lats1 和 YAP1 在 Sprague-Dawley 大鼠大脑皮质神经元中表达，TBI 后损伤区域 Lats1 和 YAP1 的磷酸化水平明显升高。此外，抑制 Lats1 不仅降低了 p-YAP1 的水平，而且减轻了神经元凋亡和神经损伤。
结论
我们的工作表明，抑制 Lats1/p-YAP1 通路减轻了 TBI 大鼠模型中的神经元凋亡和神经功能缺损。
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