a School of Nursing , Nantong University , Nantong , China.
b Department of Nursing , The Affiliated Hospital of Nantong University , Nantong , China.
Psychol Health Med. 2018 Jul;23(6):685-697. doi: 10.1080/13548506.2018.1442011. Epub 2018 Feb 28.
Sleep disturbances are common in systemic lupus erythematosus (SLE), but the features of sleep disturbances are not well understood. The aim of this study was to identify the impact of SLE on specific sleep quality domains and to determine its prevalence and associations. We performed a systematic review and meta-analysis to compare the sleep outcomes of individuals with SLE and healthy controls. PubMed, MEDLINE, EMBASE, Cochrane Library, Web of Science CNKI, VIP, CNKI and Wanfang database were searched to find the published literatures (from these databases established to May 2017). Studies were screened according to inclusion and exclusion criteria and the qualities of included studies were evaluated. The data was analyzed using Revman5.3 software. Score of the Pittsburgh Sleep Quality Index (PSQI) scoring system was used as the outcome measurement, and mean differences (MD) with 95% confidence intervals (CI) were calculated. Five studies were included, including 350 SLE and 1396 healthy controls. A total of 5 studies including 827 patients were eligible for inclusion in the systematic review and meta-analysis. In this meta-analysis, each domain of the PSQI score: subjective sleep quality (MD, .58; 95% CI, .26, .89), sleep latency(MD, .47; 95% CI, .21, .73), sleep duration (MD, .36; 95% CI, .13, .58), habitual sleep efficiency (MD, .58; 95% CI, .32, .84),sleep disorders (MD, .56; 95% CI, .34, .77), use of sleep medication (MD, .56; 95% CI, .33, .80), daytime dysfunction (MD, .57; 95% CI, .11, 1.04) and the global score (MD, 3.59; 95% CI, 1.37, 5.80) were higher in SLE women than healthy controls. Furthermore, subjective sleep quality and habitual sleep efficiency were most severely affected especially. It demonstrated that targeted interventions should be done to improve their sleep quality. Early recognition and appropriate intervention are essential to reduce the negative impact of sleep disturbances on the patient's sleep quality and outcome of their disease.
睡眠障碍在系统性红斑狼疮（SLE）中很常见，但睡眠障碍的特征尚不清楚。本研究的目的是确定 SLE 对特定睡眠质量领域的影响，并确定其患病率和相关性。我们进行了系统评价和荟萃分析，以比较 SLE 患者和健康对照者的睡眠结果。通过检索 PubMed、MEDLINE、EMBASE、Cochrane 图书馆、Web of Science CNKI、VIP、CNKI 和万方数据库（截至 2017 年 5 月），找到了已发表的文献。根据纳入和排除标准筛选研究，并评估纳入研究的质量。使用 Revman5.3 软件分析数据。匹兹堡睡眠质量指数（PSQI）评分系统的评分作为结局测量，计算均数差（MD）及其 95%置信区间（CI）。共纳入 5 项研究，包括 350 例 SLE 患者和 1396 例健康对照者。共有 5 项研究（共 827 例患者）符合纳入系统评价和荟萃分析的标准。在本荟萃分析中，PSQI 评分各领域：主观睡眠质量（MD，.58；95%CI，.26，.89）、睡眠潜伏期（MD，.47；95%CI，.21，.73）、睡眠持续时间（MD，.36；95%CI，.13，.58）、习惯性睡眠效率（MD，.58；95%CI，.32，.84）、睡眠障碍（MD，.56；95%CI，.34，.77）、使用睡眠药物（MD，.56；95%CI，.33，.80）、白天功能障碍（MD，.57；95%CI，.11，.104）和总体评分（MD，3.59；95%CI，1.37，5.80）在 SLE 女性中均高于健康对照组。此外，主观睡眠质量和习惯性睡眠效率受影响最严重。这表明应该采取有针对性的干预措施来改善 SLE 患者的睡眠质量。早期识别和适当干预对于减轻睡眠障碍对患者睡眠质量和疾病结局的负面影响至关重要。
