Márquez Francisco, Iturrieta Isabel, Calvo Mario, Urrutia Milton, Godoy-Martínez Patricio
Universidad Santo Tomás, Chile.
Instituto de Microbiología Clínica, Universidad Austral de Chile, Chile.
Rev Chilena Infectol. 2017 Oct;34(5):441-446. doi: 10.4067/S0716-10182017000500441.
Candidemia disease in Chile is not very known, despite being a very common and serious disease.
To analyze incidence and susceptibility profile of species from the genus Candida in Hospital Base Valdivia.
All candidemia cases presented between March 2009 and August 2011 in our institution were identified. Species distribution and susceptibility were studied through the disk diffusion method.
Twenty-seven candidemia episodes were studied. Incidence varied from 0.3 to 0.7 by a thousand discharges (according to clinical service). Risk factors were hospitalization, preliminary use of antibiotics, aged people and underlying disease (renal failure, heart and lung disease). The most frequent species was C. albicans, followed by C. tropicalis, C. glabrata and C. krusei. Voriconazole was the antifungal showing the best in vitro performance. Amphotericin B, fluconazole and itraconazole presented variable results.
Incidence found was superior to that described in developed countries. Candida albicans constitute the most frequent species, with high sensitivity levels to fluconazole; Candida no albicans species must be monitored. Developing new research on the topic appears as fundamental to detect potential epidemiological variations.
尽管念珠菌血症是一种非常常见且严重的疾病，但在智利对其了解并不多。
分析瓦尔迪维亚基础医院念珠菌属物种的发病率和药敏谱。
对2009年3月至2011年8月间在我们机构出现的所有念珠菌血症病例进行鉴定。通过纸片扩散法研究物种分布和药敏情况。
研究了27例念珠菌血症发作病例。发病率（按临床科室）每千例出院病例从0.3至0.7不等。危险因素包括住院、前期使用抗生素、老年人以及基础疾病（肾衰竭、心肺疾病）。最常见的物种是白色念珠菌，其次是热带念珠菌、光滑念珠菌和克柔念珠菌。伏立康唑是体外表现最佳的抗真菌药物。两性霉素B、氟康唑和伊曲康唑呈现出不同的结果。
所发现的发病率高于发达国家所描述的发病率。白色念珠菌是最常见的物种，对氟康唑具有高敏感性；非白色念珠菌物种必须进行监测。开展关于该主题的新研究对于发现潜在的流行病学变化似乎至关重要。
