Barron Mary Lee, Vanderkolk Kaitlin, Raviele Kathleen
Mary Lee Barron is an Associate Professor, Southern Illinois University Edwardsville, Edwardsville, IL. The author can be reached via e-mail at
MCN Am J Matern Child Nurs. 2018 May/Jun;43(3):153-157. doi: 10.1097/NMC.0000000000000422.
To investigate if generic Wondfo ovulation sticks (WLH) are sufficiently sensitive to the luteinizing hormone (LH) surge in urine when used with the Marquette Fertility Algorithm. The electronic hormonal fertility monitor (EHFM) is highly accurate in detecting the LH surge but cost of the monitor and the accompanying test sticks has increased over the last several years. The EHFM is sensitive to detect the LH surge at 20 milli-international units per milliliter (mIU/mL); the WLH sticks are slightly less sensitive at 25 mIU/mL.
A convenience sample of women using the Marquette Method of Natural Family Planning with the EHFM to avoid pregnancy were recruited (N = 54). Each participant used the EHFM every morning after cycle day 6 and tested morning and evening urine with the WLH stick until the day following detection of the LH surge on the EHFM.
Forty-two women provided 219 cycles. Frequency of LH surge detection was 182/219 (83.1%) for EHFM and 203/219 (92.7%) for WLH sticks. Agreement between the EHFM and the WLH on the day of the LH surge was 97.7%. High fertility readings providing a warning of peak fertility at least 5 days before peak was 67% for the WLH; the EHFM was 47.7%. Paired sample correlations for high fertility was .174 (p = .014) and paired sample differences t was -4.729 (p = .000).
The WLH stick is sufficiently sensitive to use in place of the EFHM for determining peak fertility and with the Marquette Fertility algorithm. Even with minimal use, WLH sticks cost about half the price of the monitor strips and provide more flexibility of use. Cost differences increase with the number of sticks used per cycle. Further research with a larger sample is needed to verify results.
研究通用型万孚排卵试纸（WLH）与马凯特生育算法配合使用时，对尿液中促黄体生成素（LH）激增的检测灵敏度是否足够。电子激素生育监测仪（EHFM）在检测LH激增方面高度准确，但在过去几年中，该监测仪及其配套测试试纸的成本有所增加。EHFM检测LH激增的灵敏度为每毫升20毫国际单位（mIU/mL）；WLH试纸的灵敏度略低，为25 mIU/mL。
招募了一组使用马凯特自然计划生育方法并借助EHFM来避免怀孕的女性作为便利样本（N = 54）。每位参与者在月经周期第6天之后每天早晨使用EHFM，并使用WLH试纸检测晨尿和夜尿，直至在EHFM上检测到LH激增后的次日。
42名女性提供了219个月经周期的数据。EHFM检测到LH激增的频率为182/219（83.1%），WLH试纸为203/219（92.7%）。在LH激增当天，EHFM与WLH试纸的一致性为97.7%。WLH试纸在至少比峰值提前5天发出高生育力读数以警示生育力峰值的情况为67%；EHFM为47.7%。高生育力的配对样本相关性为0.174（p = 0.014），配对样本差异t为 -4.729（p = 0.000）。
WLH试纸在用于确定生育力峰值以及与马凯特生育算法配合使用时，灵敏度足够，可以替代EHFM。即使使用量极少，WLH试纸的成本也约为监测试纸条的一半，并且使用起来更加灵活。随着每个周期使用试纸数量的增加，成本差异会增大。需要进行更大样本量的进一步研究来验证结果。
