枸橼酸西地那非诱导的视网膜毒性——视网膜电图、光学相干断层扫描及自适应光学检查结果
SILDENAFIL CITRATE INDUCED RETINAL TOXICITY-ELECTRORETINOGRAM, OPTICAL COHERENCE TOMOGRAPHY, AND ADAPTIVE OPTICS FINDINGS.
作者信息
Yanoga Fatoumata, Gentile Ronald C, Chui Toco Y P, Freund K Bailey, Fell Millie, Dolz-Marco Rosa, Rosen Richard B
机构信息
Department of Ophthalmology, New York Eye and Ear Infirmary of Mount Sinai, New York, New York.
Vitreous Retina Macula Consultants of New York, New York.
出版信息
Retin Cases Brief Rep. 2018;12 Suppl 1(Suppl 1):S33-S40. doi: 10.1097/ICB.0000000000000708.
BACKGROUND/PURPOSE: To report a case of persistent retinal toxicity associated with a high dose of sildenafil citrate intake.
METHODS
Single retrospective case report.
RESULTS
A 31-year-old white man with no medical history presented with complaints of bilateral multicolored photopsias and erythropsia (red-tinted vision), shortly after taking sildenafil citrate-purchased through the internet. Patient was found to have cone photoreceptor damage, demonstrated using electroretinogram, optical coherence tomography, and adaptive optics imaging. The patient's symptoms and the photoreceptor structural changes persisted for several months.
CONCLUSION
Sildenafil citrate is a widely used erectile dysfunction medication that is typically associated with transient visual symptoms in normal dosage. At high dosage, sildenafil citrate can lead to persistent retinal toxicity in certain individuals.
背景/目的：报告一例与高剂量枸橼酸西地那非摄入相关的持续性视网膜毒性病例。
方法
单例回顾性病例报告。
结果
一名31岁无病史的白人男性，在通过互联网购买并服用枸橼酸西地那非后不久，出现双侧多彩视幻觉和红视（视物呈红色）的症状。通过视网膜电图、光学相干断层扫描和自适应光学成像检查发现，该患者存在视锥光感受器损伤。患者的症状和光感受器结构变化持续了数月。
结论
枸橼酸西地那非是一种广泛使用的治疗勃起功能障碍的药物，正常剂量下通常会引起短暂的视觉症状。高剂量时，枸橼酸西地那非可导致某些个体出现持续性视网膜毒性。
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