Wang Jian, Ke Rui, Shi Wenhua, Yan Xin, Wang Qingting, Zhang Qianqian, Chai Limin, Li Manxiang
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, P.R. China.
Allergy Asthma Proc. 2018 Mar 1;39(2):103-109. doi: 10.2500/aap.2018.39.4109.
Psoriasis has been shown to be related to an increased risk of asthma, although the results remain inconclusive. Therefore, we performed a meta-analysis to determine whether psoriasis increases the risk of asthma.
A comprehensive search of medical literature data bases was conducted through May 2017. The pooled odds ratios (OR) and corresponding 95% confidence intervals (CI) were calculated.
A total of six studies with 66,772 psoriasis cases and 577,415 controls were included. Our meta-analysis showed that psoriasis was significantly associated with the increased risk of asthma (OR 1.32 [95% CI, 1.20-1.46]). The older age patients with psoriasis (≥50 years) (OR 1.64 [95% CI, 1.44-1.88]) had a higher risk of asthma susceptibility compared with the younger patients (20-49 years old) (OR 1.25 [95% CI 1.09-1.44]). Subgroup analysis by ethnicity indicated a significant increase in asthma risk in both Asian populations (OR 1.35 [95% CI, 1.18-1.54]) and white populations (OR 1.27 [95% CI, 1.05-1.54]) with psoriasis compared with those without psoriasis.
Results of this meta-analysis indicated that the patients with psoriasis had a higher risk of asthma susceptibility, especially among the older patients with psoriasis.
尽管结果尚无定论，但已有研究表明银屑病与哮喘风险增加有关。因此，我们进行了一项荟萃分析，以确定银屑病是否会增加哮喘风险。
对医学文献数据库进行全面检索，截至2017年5月。计算合并比值比（OR）及相应的95%置信区间（CI）。
共纳入六项研究，包括66,772例银屑病患者和577,415例对照。我们的荟萃分析表明，银屑病与哮喘风险增加显著相关（OR 1.32 [95% CI，1.20 - 1.46]）。与年轻患者（20 - 49岁）（OR 1.25 [95% CI 1.09 - 1.44]）相比，年龄较大的银屑病患者（≥50岁）（OR 1.64 [95% CI，1.44 - 1.88]）患哮喘的易感性更高。按种族进行的亚组分析表明，与无银屑病者相比，亚洲人群（OR 1.35 [95% CI，1.18 - 1.54]）和白人人群（OR 1.27 [95% CI，1.05 - 1.54]）中患银屑病者的哮喘风险均显著增加。
这项荟萃分析的结果表明，银屑病患者患哮喘的易感性更高，尤其是在年龄较大的银屑病患者中。
