Department of Paediatrics, University Hospital of Pisa, Pisa, Italy.
Imperial College and Royal Brompton Hospital, London, UK.
Thorax. 2018 Oct;73(10):980-982. doi: 10.1136/thoraxjnl-2017-210661. Epub 2018 Feb 28.
Cilia have multiple functions including olfaction. We hypothesised that olfactory function could be impaired in primary ciliary dyskinesia (PCD). Olfaction, nasal nitric oxide (nNO) and sinus CT were assessed in patients with PCD and non-PCD sinus disease, and healthy controls (no CT scan). PCD and non-PCD patients had similar severity of sinus disease. Despite this, defective olfaction was more common in patients with PCD (P<0.0001) and more severe in patients with PCD with major Transmission Electron Microscopy (TEM) abnormalities. Only in classical PCD did olfaction inversely correlate with sinusitis and nNO. We speculate that defective olfaction in PCD is primary in nature.
纤毛具有多种功能，包括嗅觉。我们假设原发性纤毛运动障碍（PCD）可能会损害嗅觉功能。我们评估了 PCD 患者和非 PCD 鼻窦疾病患者以及健康对照者（无 CT 扫描）的嗅觉、鼻内一氧化氮（nNO）和鼻窦 CT。PCD 和非 PCD 患者的鼻窦疾病严重程度相似。尽管如此，PCD 患者的嗅觉障碍更为常见（P<0.0001），并且在主要透射电子显微镜（TEM）异常的 PCD 患者中更为严重。只有在经典 PCD 中，嗅觉才与鼻窦炎和 nNO 呈负相关。我们推测 PCD 中的嗅觉缺陷是原发性的。
