Hansky J, Stern A I, Korman M G, Waugh J
Aust N Z J Med. 1979 Dec;9(6):637-8. doi: 10.1111/j.1445-5994.1979.tb04192.x.
Serum immunoreactive gastrin was measured in 14 patients with duodenal ulcer before and during a 12-month course of cimetidine 400 mg bd. All patients were symptomatically well during the cimetidine therapy and both basal gastrin and that in response to a protein rich meal were assessed before, at six months and at 12 months during therapy. The basal and post-prandial gastrin were significantly higher at six and 12 months on cimetidine than before cimetidine but the six and 12 month levels were similar. This study thus shows that the progressive increase in serum gastrin during six months of continuous cimetidine therapy does not occur beyond this time period.
对14例十二指肠溃疡患者在服用西咪替丁400毫克每日两次、疗程为12个月之前及期间测量血清免疫反应性胃泌素。在西咪替丁治疗期间，所有患者症状均良好，并且在治疗前、治疗6个月时和12个月时评估基础胃泌素以及对富含蛋白质餐的反应性胃泌素。服用西咪替丁6个月和12个月时的基础胃泌素和餐后胃泌素显著高于服用西咪替丁之前，但6个月和12个月时的水平相似。因此，本研究表明，在持续6个月的西咪替丁治疗期间血清胃泌素的逐渐升高在此时间段之后不会发生。
