Hansky J, Stern A I, Korman M G, Waugh J
Dig Dis Sci. 1979 Jun;24(6):468-70. doi: 10.1007/BF01299830.
Basal and food-stimulated gastrin were measured in 16 patients with duodenal ulcer before and during long-term maintenance therapy with 400 mg cimetidine twice daily. Basal gastrin (mean +/- SE) rose significantly from 27.5 +/- 3.1 pmol/liter precimetidine to 32.8 +/- 2.1, 37.2 +/- 2.6, and 38.5 +/- 3.3 pmol/liter at 1, 3, and 6 months, respectively. The total integrated gastrin response to a protein meal was 1.67 +/- 0.18 nmol/liter/120 min pre-, and 2.54 +/- 0.35, 3.29 +/- 0.3, and 4.36 +/- 0.4 nmol/liter/120 min at 1, 3, and 6 months, respectively. These increases were significantly higher at each time period. This study has thus demonstrated a progressive increase in both basal and food-stimulated gastrin during cimetidine therapy, and this increase could theoretically lead to an increase in gastric acid secretion following cessation of cimetidine.
对16例十二指肠溃疡患者在每日两次服用400毫克西咪替丁进行长期维持治疗之前及治疗期间，测量其基础胃泌素水平和食物刺激后的胃泌素水平。基础胃泌素（均值±标准误）在服用西咪替丁前为27.5±3.1皮摩尔/升，在第1、3和6个月时分别显著升至32.8±2.1、37.2±2.6和38.5±3.3皮摩尔/升。对蛋白质餐的胃泌素总积分反应在服用前为1.67±0.18纳摩尔/升/120分钟，在第1、3和6个月时分别为2.54±0.35、3.29±0.3和4.36±0.4纳摩尔/升/120分钟。这些增加在每个时间段均显著更高。因此，本研究表明在西咪替丁治疗期间基础胃泌素水平和食物刺激后的胃泌素水平均逐渐升高，并且从理论上讲，这种升高可能导致停用西咪替丁后胃酸分泌增加。
