Forrest J A, Fettes M R, McLoughlin G P, Heading R C
Gut. 1979 May;20(5):404-7. doi: 10.1136/gut.20.5.404.
Gastric acid secretion, gastric emptying, fasting serum gastrin and the serum gastrin response to a meal were measured in duodenal ulcer patients before, and at least five days after completing prolonged treatment with cimetidine (1 or 2 g/day for four or eight weeks followed by 600 mg twice daily for six months). Fasting serum gastrin and the gastrin response were also measured during treatment. Compared with pretreatment values, fasting serum gastrin concentrations were raised both during and five to 31 days after stopping treatment (P less than or equal to 0.02). The integrated gastrin response and the rate of gastric emptying of the solid component of the meal were increased during treatment (P less than 0.001 and P less than 0.002 respectively) but returned to pretreatment levels after stopping therapy. No significant changes were observed in the basal or maximal acid outputs or the rate of emptying of the liquid component of the meal. The results imply that the hypergastrinaemia associated with long-term cimetidine therapy does not result in increased gastric acid secretion.
在十二指肠溃疡患者中，在使用西咪替丁进行长期治疗前以及完成治疗至少五天后（1或2克/天，持续四周或八周，随后600毫克，每日两次，持续六个月），测量胃酸分泌、胃排空、空腹血清胃泌素以及进食后血清胃泌素反应。在治疗期间也测量空腹血清胃泌素和胃泌素反应。与治疗前值相比，停止治疗期间以及停止治疗后五至31天，空腹血清胃泌素浓度均升高（P≤0.02）。治疗期间，进食后胃泌素综合反应和固体成分胃排空率增加（分别为P＜0.001和P＜0.002），但停止治疗后恢复到治疗前水平。基础或最大胃酸分泌量以及进食后液体成分排空率未观察到显著变化。结果表明，与长期西咪替丁治疗相关的高胃泌素血症不会导致胃酸分泌增加。
