Bhandari Ramji K
Division of Biological Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA.
Environ Epigenet. 2016 Jan 30;2(1):dvv010. doi: 10.1093/eep/dvv010. eCollection 2016 Jan.
Ability of environmental stressors to induce transgenerational diseases has been experimentally demonstrated in plants, worms, fish, and mammals, indicating that exposures affect not only human health but also fish and ecosystem health. Small aquarium fish have been reliable model to study genetic and epigenetic basis of development and disease. Additionally, fish can also provide better, economic opportunity to study transgenerational inheritance of adverse health and epigenetic mechanisms. Molecular mechanisms underlying germ cell development in fish are comparable to those in mammals and humans. This review will provide a short overview of long-term effects of environmental chemical contaminant exposure in various models, associated epigenetic mechanisms, and a perspective on fish as model to study environmentally induced transgenerational inheritance of altered phenotypes.
环境应激源诱发跨代疾病的能力已在植物、蠕虫、鱼类和哺乳动物中得到实验证明，这表明接触不仅会影响人类健康，还会影响鱼类和生态系统健康。小型水族箱鱼类一直是研究发育和疾病的遗传及表观遗传基础的可靠模型。此外，鱼类还能为研究不良健康的跨代遗传和表观遗传机制提供更好的经济机会。鱼类生殖细胞发育的分子机制与哺乳动物和人类的相似。本综述将简要概述环境化学污染物暴露在各种模型中的长期影响、相关的表观遗传机制，并展望鱼类作为研究环境诱导的表型改变跨代遗传的模型。
