Drugeon H B, Caillon J, Moinard D, Juvin M E, Pirault J L
Presse Med. 1986 Dec 20;15(46):2297-302.
The bactericidal activity of piperacillin was evaluated by the kill rate kinetics method. Piperacillin compared with amoxicillin, amdinocillin, mezlocillin, cefotaxime, ceftazidime and latamoxef. Against E. coli, piperacillin and antibiotics electively bound to penicillin-binding protein (PBP) 3 had the same, mainly time-dependent, bactericidal activity. Antibiotics bound to PBP 1 and 2 mainly have a dose-dependent activity. The bactericidal activity of piperacillin against E. coli was enhanced when the drug was combined with amoxicillin and amdinocillin; in contrast, the kill rate remained unmodified when piperacillin was combined with latamoxef. When the piperacillin-amikacin combination was tested against Pseudomonas aeruginosa, Enterobacter cloacae, Escherichia coli and Serratia marcescens, early synergism (5th hour), was weak, but after 24 hours piperacillin reduced the regrowth observed with the aminoglycoside, and synergism was much more pronounced irrespective of the species investigated.
采用杀菌速率动力学方法评估哌拉西林的杀菌活性。将哌拉西林与阿莫西林、氨比西林、美洛西林、头孢噻肟、头孢他啶和拉氧头孢进行比较。针对大肠杆菌，哌拉西林和选择性结合青霉素结合蛋白（PBP）3的抗生素具有相同的、主要是时间依赖性的杀菌活性。结合PBP 1和2的抗生素主要具有剂量依赖性活性。当哌拉西林与阿莫西林和氨比西林联合使用时，其对大肠杆菌的杀菌活性增强；相反，当哌拉西林与拉氧头孢联合使用时，杀菌速率保持不变。当测试哌拉西林-阿米卡星组合对铜绿假单胞菌、阴沟肠杆菌、大肠杆菌和粘质沙雷氏菌的作用时，早期协同作用（第5小时）较弱，但24小时后哌拉西林减少了氨基糖苷类药物观察到的再生长，并且无论所研究的菌种如何，协同作用都更为明显。
