Department of Pediatrics A, The Edmond and Lily Safra Children's Hospital, Chaim Sheba Medical Center, Ramat-Gan, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Pediatr Diabetes. 2018 Jun;19(4):749-755. doi: 10.1111/pedi.12653. Epub 2018 Mar 1.
Disordered eating behaviors (DEBs) may lead to full blown eating disorders. Both type 1 diabetes mellitus (T1DM) and celiac disease (CD) have been linked to DEBs.
To compare the presence of DEBs between adolescents and young adults with a dual diagnosis of T1DM and CD, and individuals with only one of the diagnoses.
Individuals with a dual diagnosis of T1DM and CD ("T1DM + CD group" n = 39), with a diagnosis of T1DM only ("T1DM group" n = 97) and with a diagnosis of CD only ("CD group" n = 267) filled the Eating Attitude Test-26 (EAT-26) questionnaire. Those with T1DM completed in addition to the Diabetes Eating Problem Survey-Revised (DEPS-R).
The study population comprised of 403 individuals, of whom 65% were females. There were no statistically significant differences among the groups in distribution of sex, age, hemoglobin A1c (HbA1c) levels, age of disease diagnosis and duration. The prevalence of DEBs in the T1DM + CD group was 3-fold higher (26.0%) than in the T1DM (8.2%) and CD (8.2%) groups (P = .003). This trend was observed for both females and males. Multivariate analysis demonstrated that the T1DM + CD group had an increased risk for DEBs (odds ratio, OR: 4.7, 95% confidence interval, CI: 1.9-11.2, P = .001) after adjustment for age, sex, and body mass index. Additionally, being female, older and overweight increased the risk for DEBs. HbA1c values were not associated with an increased DEBs rate.
Individuals with the dual diagnoses of T1DM and CD have an increased likelihood to develop DEBs compared to those with only one of these diagnoses.
饮食失调行为（DEBs）可能导致完全型饮食障碍。1 型糖尿病（T1DM）和乳糜泻（CD）都与 DEBs 有关。
比较同时患有 1 型糖尿病和乳糜泻（T1DM+CD 组）和仅患有其中一种疾病（T1DM 组和 CD 组）的青少年和年轻成人中 DEBs 的存在情况。
同时患有 1 型糖尿病和乳糜泻（“T1DM+CD 组”，n=39）、仅患有 1 型糖尿病（“T1DM 组”，n=97）和仅患有乳糜泻（“CD 组”，n=267）的个体填写了饮食态度测试-26（EAT-26）问卷。T1DM 患者除了填写糖尿病饮食问题调查修订版（DEPS-R）外，还填写了糖尿病饮食问题调查修订版。
研究人群包括 403 名个体，其中 65%为女性。三组在性别、年龄、糖化血红蛋白（HbA1c）水平、疾病诊断年龄和病程的分布上无统计学差异。T1DM+CD 组 DEBs 的患病率（26.0%）是 T1DM（8.2%）和 CD（8.2%）组的 3 倍（P=0.003）。这种趋势在女性和男性中均观察到。多变量分析表明，在调整年龄、性别和体重指数后，T1DM+CD 组发生 DEBs 的风险增加（优势比，OR：4.7，95%置信区间，CI：1.9-11.2，P=0.001）。此外，女性、年龄较大和超重会增加发生 DEBs 的风险。HbA1c 值与 DEBs 发生率增加无关。
与仅患有其中一种疾病的个体相比，同时患有 1 型糖尿病和乳糜泻的个体发生 DEBs 的可能性更大。
