Xiong Wei, Zhao Yunfeng, Gong Sugang, Zhao Qinhua, Liu Jinming
1 Department of Cardiopulmonary Circulation, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
2 Department of Respiratory Medicine, Shanghai Punan Hospital, Pudong New District, Shanghai, China.
Pulm Circ. 2018 Apr-Jun;8(2):2045894018765835. doi: 10.1177/2045894018765835. Epub 2018 Mar 1.
The long-term oxygen therapy (LTOT) for patients with chronic obstructive pulmonary disease (COPD) has been shown to increase survival in patients with severe resting hypoxemia. The adherence to LTOT may also simultaneously affect the development of concomitant pulmonary hypertension (PH) due to COPD with hypoxemia. We retrospectively reviewed 276 cases of COPD with or without PH assessed by right heart catheterization (RHC) to investigate whether adherence to continuous LTOT had a prophylactic effect on the development of PH in a time interval of two years. In contrast to the patients in the non-compliance group (PH prevalence 64.2%), patients with excellent compliance of adhering to continuous LTOT > 15 h per day in the compliance group (PH prevalence 37.6%) are more liable to postpone the development of PH due to hypoxic COPD for at least two years. Adherence to LTOT ≥ 15 h/day is strongly recommended in order to lower the risk and delay the development of consequent PH in COPD with hypoxemia.
长期氧疗（LTOT）已被证明可提高重度静息性低氧血症的慢性阻塞性肺疾病（COPD）患者的生存率。LTOT的依从性也可能同时影响合并低氧血症的COPD患者并发肺动脉高压（PH）的发生发展。我们回顾性分析了276例经右心导管检查（RHC）评估的伴或不伴PH的COPD患者，以研究在两年时间内持续LTOT的依从性是否对PH的发生具有预防作用。与不依从组患者（PH患病率64.2%）相比，依从组中每天坚持持续LTOT超过15小时的依从性良好的患者（PH患病率37.6%）更有可能将低氧性COPD所致PH的发生推迟至少两年。强烈建议坚持LTOT≥15小时/天，以降低合并低氧血症的COPD患者发生后续PH的风险并延缓其发展。
