Waghmare Indrayani, Page-McCaw Andrea
Department of Cell and Developmental Biology and Program in Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
Genes (Basel). 2018 Feb 27;9(3):127. doi: 10.3390/genes9030127.
Wnt signaling is a conserved regulator of stem cell behaviors, and the germarium has been an important model tissue for the study of stem cell maintenance, differentiation, and proliferation. Here we review Wnt signaling in the germarium, which houses two distinct types of ovarian stem cells: the anteriorly located germline stem cells (GSCs), which give rise to oocytes; and the mid-posteriorly located follicle stem cells (FSCs), which give rise to the somatic follicle cells that cover a developing oocyte. The maintenance and proliferation of GSCs and FSCs is regulated by the stem cell niches, whereas differentiation of the germline is regulated by the differentiation niche. Four distinct Wnt ligands are localized in the germarium, and we focus review on how these Wnt ligands and Wnt signaling affects maintenance and differentiation of both germline and follicle stem cells in their respective niches.
Wnt信号通路是干细胞行为的保守调节因子，而卵巢生殖区一直是研究干细胞维持、分化和增殖的重要模型组织。在此，我们综述卵巢生殖区中的Wnt信号通路，该区域存在两种不同类型的卵巢干细胞：位于前部的生殖系干细胞（GSCs），可产生卵母细胞；以及位于中后部的卵泡干细胞（FSCs），可产生覆盖发育中卵母细胞的体细胞卵泡细胞。GSCs和FSCs的维持和增殖由干细胞微环境调节，而生殖系的分化则由分化微环境调节。四种不同的Wnt配体定位于卵巢生殖区，我们重点综述这些Wnt配体和Wnt信号通路如何影响生殖系和卵泡干细胞在各自微环境中的维持和分化。
