Imunologia Celular e Molecular, Instituto René Rachou, Avenida Augusto de Lima, 1715, sala 406, Belo Horizonte 30190-002, Brazil.
Santa Casa de Misericórdia de Santo Antônio do Monte, Santo Antônio do Monte 35560-000, Brazil.
Viruses. 2018 Feb 28;10(3):104. doi: 10.3390/v10030104.
The inflammatory process plays a major role in the prognosis of dengue. In this context, the eicosanoids may have considerable influence on the regulation of the -induced inflammatory process. To quantify the molecules involved in the cyclooxygenase and lipoxygenase pathways during infection, plasma levels of thromboxane A2, prostaglandin E2 and leukotriene B4; mRNA levels of thromboxane A2 synthase, prostaglandin E2 synthase, leukotriene A4 hydrolase, cyclooxygenase-2 and 5-lipoxygenase; and the levels of lipid bodies in peripheral blood leukocytes collected from IgM-positive and IgM-negative volunteers with mild dengue, and non-infected volunteers, were evaluated. infection increases the levels of thromboxane A2 in IgM-positive individuals as well as the amount of lipid bodies in monocytes in IgM-negative individuals. We suggest that increased levels of thromboxane A2 in IgM-positive individuals plays a protective role against the development of severe symptoms of dengue, such as vascular leakage.
炎症过程在登革热的预后中起着重要作用。在这种情况下，类二十烷酸可能对调节登革热诱导的炎症过程有相当大的影响。为了定量检测 感染过程中环氧化酶和脂氧化酶途径中涉及的分子，我们检测了来自 IgM 阳性和 IgM 阴性的轻度登革热患者以及未感染志愿者的血浆血栓素 A2、前列腺素 E2 和白三烯 B4 水平；血栓素 A2 合酶、前列腺素 E2 合酶、白三烯 A4 水解酶、环氧合酶-2 和 5-脂氧合酶的 mRNA 水平；以及外周血白细胞中的脂滴水平。 感染增加了 IgM 阳性个体的血栓素 A2 水平，以及 IgM 阴性个体单核细胞中的脂滴数量。我们认为，IgM 阳性个体中血栓素 A2 水平的升高对防止登革热的严重症状（如血管渗漏）的发展起到了保护作用。
