Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.
Cancer Biology Laboratory and DBT-AIST International Laboratory for Advanced Biomedicine (DAILAB), Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam, 781039, India.
Pharmacol Res. 2018 Apr;130:259-272. doi: 10.1016/j.phrs.2018.02.017. Epub 2018 Feb 27.
Despite the significant advancements in the diagnosis and treatment of cancer, it still remains one of the most fatal diseases in the world due to the lack of sensitive diagnosis methods and effective drugs. Therefore, discovering novel therapies that are safe, efficacious and affordable are required for the better management of this disease. Tocotrienols, analogues of vitamin E have gained increased attention due to their safety and efficacy. Extensive research over the past several years has strongly indicated that tocotrienols can efficiently prevent/inhibit the growth of different cancers such as cancers of blood, brain, breast, cervical, colon, liver, lung, pancreas, prostate, skin, stomach etc. This is mainly accredited to their ability to modulate various molecular targets involved in cancer cell proliferation, survival, invasion, angiogenesis, and metastasis such as NF-κB, STAT3, Akt/mTOR, etc. In addition, increasing lines of evidence has shown that tocotrienols can sensitize cancer cells to chemotherapeutic agents such as celecoxib, doxorubicin, erlotinib, gefitinib, gemcitabine, paclitaxel, statin etc. Moreover, several clinical trials have confirmed the safety and tolerability of tocotrienols in humans. This review summarizes the potential of tocotrienols for the prevention and treatment of different cancers based on the available in vitro, in vivo and clinical studies.
尽管癌症的诊断和治疗取得了重大进展，但由于缺乏敏感的诊断方法和有效的药物，癌症仍然是世界上最致命的疾病之一。因此，需要发现安全、有效和负担得起的新疗法来更好地治疗这种疾病。生育三烯酚，维生素 E 的类似物，由于其安全性和有效性而受到越来越多的关注。过去几年的广泛研究强烈表明，生育三烯酚可以有效地预防/抑制不同癌症的生长，如血液癌、脑癌、乳腺癌、宫颈癌、结肠癌、肝癌、肺癌、胰腺癌、前列腺癌、皮肤癌、胃癌等。这主要归因于它们调节参与癌细胞增殖、存活、侵袭、血管生成和转移的各种分子靶标的能力，如 NF-κB、STAT3、Akt/mTOR 等。此外，越来越多的证据表明，生育三烯酚可以使癌细胞对化疗药物如塞来昔布、阿霉素、厄洛替尼、吉非替尼、吉西他滨、紫杉醇、他汀类药物等敏感。此外，几项临床试验已经证实了生育三烯酚在人类中的安全性和耐受性。本综述根据现有的体外、体内和临床研究，总结了生育三烯酚预防和治疗不同癌症的潜力。
