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嗅觉受体作为人类乳腺癌组织中的生物标志物

Olfactory Receptors as Biomarkers in Human Breast Carcinoma Tissues.

作者信息

Weber Lea, Maßberg Désirée, Becker Christian, Altmüller Janine, Ubrig Burkhard, Bonatz Gabriele, Wölk Gerhard, Philippou Stathis, Tannapfel Andrea, Hatt Hanns, Gisselmann Günter

机构信息

Department of Cell Physiology, Ruhr-University Bochum, Bochum, Germany.

Cologne Center for Genomics, University of Cologne, Cologne, Germany.

出版信息

Front Oncol. 2018 Feb 15;8:33. doi: 10.3389/fonc.2018.00033. eCollection 2018.

DOI:10.3389/fonc.2018.00033
PMID:29497600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5818398/
Abstract

Olfactory receptors (ORs) are known to be expressed in a variety of human tissues and act on different physiological processes, such as cell migration, proliferation, or secretion and have been found to function as biomarkers for carcinoma tissues of prostate, lung, and small intestine. In this study, we analyzed the OR expression profiles of several different carcinoma tissues, with a focus on breast cancer. The expression of OR2B6 was detectable in breast carcinoma tissues; here, transcripts of OR2B6 were detected in 73% of all breast carcinoma cell lines and in over 80% of all of the breast carcinoma tissues analyzed. Interestingly, there was no expression of OR2B6 observed in healthy tissues. Immunohistochemical staining of OR2B6 in breast carcinoma tissues revealed a distinct staining pattern of carcinoma cells. Furthermore, we detected a fusion transcript containing part of the coding exon of OR2B6 as a part of a splice variant of the histone HIST1H2BO transcript. In addition, in cancer tissues and cell lines derived from lung, pancreas, and brain, OR expression patterns were compared to that of corresponding healthy tissues. The number of ORs detected in lung carcinoma tissues was significantly reduced in comparison to the surrounding healthy tissues. In pancreatic carcinoma tissues, OR4C6 was considerably more highly expressed in comparison to the respective healthy tissues. We detected OR2B6 as a potential biomarker for breast carcinoma tissues.

摘要

已知嗅觉受体（ORs）在多种人体组织中表达，并作用于不同的生理过程，如细胞迁移、增殖或分泌，且已发现其可作为前列腺、肺和小肠癌组织的生物标志物。在本研究中，我们分析了几种不同癌组织的OR表达谱，重点关注乳腺癌。在乳腺癌组织中可检测到OR2B6的表达；在此，在所有乳腺癌细胞系的73%以及所分析的所有乳腺癌组织的80%以上中检测到了OR2B6的转录本。有趣的是，在健康组织中未观察到OR2B6的表达。乳腺癌组织中OR2B6的免疫组化染色显示癌细胞有独特的染色模式。此外，我们检测到一个包含OR2B6部分编码外显子的融合转录本，它是组蛋白HIST1H2BO转录本剪接变体的一部分。另外，在源自肺、胰腺和脑的癌组织及细胞系中，将OR表达模式与相应健康组织的进行了比较。与周围健康组织相比，肺癌组织中检测到的OR数量显著减少。在胰腺癌组织中，与各自的健康组织相比，OR4C6的表达明显更高。我们检测到OR2B6可作为乳腺癌组织的潜在生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/28e28fe43ea8/fonc-08-00033-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/158d982f6acf/fonc-08-00033-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/9462d625df98/fonc-08-00033-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/d448a702e318/fonc-08-00033-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/9bdd0617f3c3/fonc-08-00033-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/28e28fe43ea8/fonc-08-00033-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/158d982f6acf/fonc-08-00033-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/9462d625df98/fonc-08-00033-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/d448a702e318/fonc-08-00033-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/9bdd0617f3c3/fonc-08-00033-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7ea/5818398/28e28fe43ea8/fonc-08-00033-g005.jpg

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