Tang Yi, Tian Ye, Zhang Chun-Xia, Wang Guo-Tai
Shaanxi University of Chinese Medicine, Xianyang, China.
Department of Oncology, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, China.
Cell Biochem Biophys. 2025 Mar;83(1):295-305. doi: 10.1007/s12013-024-01556-7. Epub 2024 Oct 4.
Olfactory receptors (ORs) are a class of G protein-coupled receptors (GPCR) widely distributed in olfactory sensory neurons and various non-olfactory tissues, serving significant physiological and pathological functions in the human body. Increasing evidence reveals the heightened expression of olfactory receptors in tumorous tissues and cells alongside normal tissues. Olfactory receptors have demonstrated influence over tumor cell proliferation and metastasis, establishing a close relationship with tumor initiation and progression. This review highlights the specific molecular actions and signaling pathways of olfactory receptors in the development of human tumors. The potential for precise tumor diagnosis and targeted therapy through therapeutic targeting of olfactory receptors as an adjunct anticancer treatment strategy is being considered.
嗅觉受体（ORs）是一类G蛋白偶联受体（GPCR），广泛分布于嗅觉感觉神经元和各种非嗅觉组织中，在人体中发挥着重要的生理和病理功能。越来越多的证据表明，与正常组织相比，嗅觉受体在肿瘤组织和细胞中的表达升高。嗅觉受体已被证明对肿瘤细胞的增殖和转移有影响，与肿瘤的发生和发展密切相关。本文综述了嗅觉受体在人类肿瘤发生发展中的具体分子作用和信号通路。目前正在考虑将靶向嗅觉受体作为一种辅助抗癌治疗策略，用于精确肿瘤诊断和靶向治疗的潜力。
