Ranzani Marco, Iyer Vivek, Ibarra-Soria Ximena, Del Castillo Velasco-Herrera Martin, Garnett Mathew, Logan Darren, Adams David J
Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, UK.
Genetics of Behaviour, The Wellcome Trust Sanger Institute, Hinxton, UK.
Wellcome Open Res. 2017 Feb 10;2:9. doi: 10.12688/wellcomeopenres.10646.1.
Olfactory receptors (ORs) recognize odorant molecules and activate a signal transduction pathway that ultimately leads to the perception of smell. This process also modulates the apoptotic cycle of olfactory sensory neurons in an olfactory receptor-specific manner. Recent reports indicate that some olfactory receptors are expressed in tissues other than the olfactory epithelium suggesting that they may have pleiotropic roles. We investigated the expression of 301 olfactory receptor genes in a comprehensive panel of 968 cancer cell lines. Forty-nine per cent of cell lines show expression of at least one olfactory receptor gene. Some receptors display a broad pattern of expression across tumour types, while others were expressed in cell lines from a particular tissue. Additionally, most of the cancer cell lines expressing olfactory receptors express the effectors necessary for OR-mediated signal transduction. Remarkably, among cancer cell lines, is exclusively expressed in melanoma lines. We also confirmed the expression of in human melanomas, but not in normal melanocytes. The pattern of expression is suggestive of a functional role in the development and/or progression of melanoma. Some olfactory receptors may contribute to tumorigenesis.
嗅觉受体（ORs）识别气味分子并激活一条信号转导通路，该通路最终导致嗅觉的产生。这一过程还以嗅觉受体特异性的方式调节嗅觉感觉神经元的凋亡周期。最近的报道表明，一些嗅觉受体在嗅觉上皮以外的组织中表达，这表明它们可能具有多效性作用。我们在由968个癌细胞系组成的综合样本中研究了301个嗅觉受体基因的表达情况。49%的细胞系显示至少有一个嗅觉受体基因表达。一些受体在多种肿瘤类型中呈现广泛的表达模式，而其他受体则在特定组织来源的细胞系中表达。此外，大多数表达嗅觉受体的癌细胞系表达OR介导的信号转导所需的效应器。值得注意的是，在癌细胞系中，[此处原文缺失具体基因名称]仅在黑色素瘤细胞系中表达。我们还证实了[此处原文缺失具体基因名称]在人类黑色素瘤中的表达，但在正常黑素细胞中不表达。[此处原文缺失具体基因名称]的表达模式提示其在黑色素瘤的发生和/或发展中具有功能性作用。一些嗅觉受体可能有助于肿瘤发生。
