Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.
Acta Ophthalmol. 2018 Sep;96(6):641-647. doi: 10.1111/aos.13685. Epub 2018 Mar 2.
To investigate whether intraocular silicone oil (SO) tamponade is associated with functional changes in patients with both macula-on and macula-off rhegmatogenous retinal detachments (RRDs).
Prospective observational cohort study of patients with RRD treated by vitrectomy with gas or SO tamponade at the University Medical Center Utrecht. Outcome was best-corrected visual acuity (BCVA) and retinal sensitivity on microperimetry 2 months after surgery.
In total, 40 eyes were included. There are 10 eyes in each of the following groups: macula-on RRD and gas, macula-on RRD and SO, macula-off RRD and gas, and macula-off RRD and SO. Median retinal sensitivity on microperimetry was decreased following SO tamponade compared to gas tamponade for both macula-on and macula-off RRD (p < 0.037).
Foveal sensitivity was decreased in eyes after SO tamponade compared to gas tamponade. These effects were observed in patients with macula-on as well as macula-off RRD. Although further investigation is warranted to validate our results and to study underlying mechanisms, retinal surgeons need to be aware of these findings after the use of SO tamponade.
研究眼内硅油（SO）填充是否与黄斑区在位和黄斑区脱离的孔源性视网膜脱离（RRD）患者的功能变化有关。
对乌得勒支大学医学中心接受玻璃体切除术联合气体或 SO 填充治疗的 RRD 患者进行前瞻性观察性队列研究。术后 2 个月，通过最佳矫正视力（BCVA）和微视野计评估视网膜敏感性。
共纳入 40 只眼。以下每组各有 10 只眼：黄斑区在位伴气体填充、黄斑区在位伴 SO 填充、黄斑区脱离伴气体填充和黄斑区脱离伴 SO 填充。与气体填充相比，SO 填充后，无论是黄斑区在位还是黄斑区脱离的 RRD，微视野计测量的视网膜敏感性中位数均降低（p < 0.037）。
与气体填充相比，SO 填充后眼内的中心凹敏感性降低。这些影响在黄斑区在位和黄斑区脱离的 RRD 患者中均观察到。尽管需要进一步的研究来验证我们的结果并研究潜在的机制，但视网膜外科医生在使用 SO 填充后需要注意这些发现。
