Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin 150081, China.
School of Public Health, Jiamusi University, Jiamusi 154007, China.
Nutrients. 2018 Mar 2;10(3):296. doi: 10.3390/nu10030296.
To assess the association between dietary magnesium intake and hyperuricemia in United States (US) adults, we extracted 26,796 US adults aged 20-85 years from the National Health and Nutrition Examination Survey (NHANES) in 2001-2014. All dietary intake was measured through 24 h dietary recall method. Multivariable logistic regression analysis was performed to investigate the association between magnesium intake and hyperuricemia after adjusting for several important confounding variables. When compared to the lowest quintile (Q1), for male, adjusted odds ratios (ORs) of hyperuricemia in the second quintile (Q2) to the fifth quintile (Q5) of the magnesium intake were 0.83 (95% CI: 0.72-0.95), 0.74 (0.64-0.85), 0.78 (0.67-0.90), and 0.70 (0.58-0.84, for trend = 0.0003), respectively. For female, OR was 0.75 (0.62-0.90) in the fourth quintile (Q4) ( for trend = 0.0242). As compared to Q4 of magnesium intake (contains recommended amount), the relative odds of hyperuricemia were increased by 1.29 times in Q1 (OR = 1.29, 1.11-1.50) in male. The ORs were 1.33 (1.11-1.61) in Q1, 1.27 (1.07-1.50) in Q2 in female. Our results indicated that increased magnesium intake was associated with decreased hyperuricemia risk. It also indicated the importance of recommended dietary allowance (RDA) of magnesium and the potential function of magnesium intake in the prevention of hyperuricemia.
为了评估美国成年人饮食镁摄入量与高尿酸血症之间的关系，我们从 2001 年至 2014 年的国家健康和营养调查（NHANES）中提取了 26796 名年龄在 20-85 岁的美国成年人。所有饮食摄入均通过 24 小时饮食回忆法进行测量。采用多变量逻辑回归分析，调整了几个重要的混杂变量后，研究了镁摄入量与高尿酸血症之间的关系。与最低五分位数（Q1）相比，男性中镁摄入量第二五分位数（Q2）至第五五分位数（Q5）的高尿酸血症校正比值比（OR）分别为 0.83（95%可信区间：0.72-0.95）、0.74（0.64-0.85）、0.78（0.67-0.90）和 0.70（0.58-0.84，趋势=0.0003）。对于女性，第四五分位数（Q4）的 OR 为 0.75（0.62-0.90）（趋势=0.0242）。与镁摄入量 Q4（包含推荐量）相比，男性镁摄入量 Q1 的高尿酸血症相对风险增加了 1.29 倍（OR=1.29，1.11-1.50）。女性 Q1 的 OR 为 1.33（1.11-1.61），Q2 的 OR 为 1.27（1.07-1.50）。我们的结果表明，增加镁摄入量与降低高尿酸血症风险有关。这也表明了推荐膳食允许量（RDA）的镁和镁摄入量在预防高尿酸血症方面的潜在作用的重要性。
