Li Mingming, Wu Mengjiao, Zhu Hua, Hua Yulin, Ma Zijun, Yao Jiayi, Feng Bin, Shi Bimin
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Soochow University, Suzhou 215006, China.
Int J Endocrinol. 2022 Apr 21;2022:2009724. doi: 10.1155/2022/2009724. eCollection 2022.
Tenascin-C (TNC), an extracellular matrix glycoprotein, is elevated in inflammatory and cardiovascular pathologies, whereas alarin, a novel orexigenic peptide, participates in insulin resistance and glycometabolism. The roles of these molecules in individuals with cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM), clinical conditions associating with metabolic disorders, and chronic inflammation, remain controversial. Our study aimed at determining the potential role of TNC and alarin in CVD adult patients with T2DM.
This was a cross-sectional study. Basic and clinical information for 250 patients with T2DM were analyzed. Based on their cardiovascular disease status, participants were assigned into the CVD and non-CVD groups. Serum TNC and alarin levels were assessed by enzyme-linked immunosorbent assay (ELISA).
Serum TNC and alarin concentrations in the CVD group were significantly higher than those of the non-CVD group. Moreover, serum TNC levels were positively correlated with age, waist circumference, and waist-hip ratio; however, they were negatively correlated with TC, LDL-C, and eGFR levels. Alarin levels were positively correlated with BMI, waist circumference, and hip circumference. In logistic regression models, TNC and alarin were also established to be independent determinants for CVD in T2DM patients and their increases were associated with CVD severity. Receiver operating characteristic (ROC) curve analysis showed that the area under curve (AUC) values for TNC and alarin were 0.68 and 0.67, respectively. TNC and alarin were good predictors of CVD occurrence. When the cutoff value for TNC was 134.05 pg/mL, its sensitivity was 69.47% while its specificity was 61.29%. When the cutoff value for alarin was 142.69 pg/mL, sensitivity and specificity were 38.95% and 90.97%, respectively.
Elevated TNC and alarin levels are independently associated with the occurrence and severity of CVD in T2DM individuals. Therefore, these two biomarkers are potential diagnostic and prognostic indicators for CVD in diabetics.
腱生蛋白-C（TNC）是一种细胞外基质糖蛋白，在炎症和心血管疾病中水平升高，而阿拉瑞林是一种新型促食欲肽，参与胰岛素抵抗和糖代谢。这些分子在患有心血管疾病（CVD）和2型糖尿病（T2DM）的个体中的作用，这两种临床情况与代谢紊乱和慢性炎症相关，仍存在争议。我们的研究旨在确定TNC和阿拉瑞林在患有T2DM的CVD成年患者中的潜在作用。
这是一项横断面研究。分析了250例T2DM患者的基本和临床信息。根据心血管疾病状况，将参与者分为CVD组和非CVD组。采用酶联免疫吸附测定（ELISA）评估血清TNC和阿拉瑞林水平。
CVD组血清TNC和阿拉瑞林浓度显著高于非CVD组。此外，血清TNC水平与年龄、腰围和腰臀比呈正相关；然而，它们与总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）和估算肾小球滤过率（eGFR）水平呈负相关。阿拉瑞林水平与体重指数（BMI）、腰围和臀围呈正相关。在逻辑回归模型中，TNC和阿拉瑞林也被确定为T2DM患者CVD的独立决定因素，它们的升高与CVD严重程度相关。受试者工作特征（ROC）曲线分析显示，TNC和阿拉瑞林的曲线下面积（AUC）值分别为0.68和0.67。TNC和阿拉瑞林是CVD发生的良好预测指标。当TNC的截断值为134.05 pg/mL时，其敏感性为69.47%，特异性为61.29%。当阿拉瑞林的截断值为142.69 pg/mL时，敏感性和特异性分别为38.95%和90.97%。
TNC和阿拉瑞林水平升高与T2DM个体中CVD的发生和严重程度独立相关。因此，这两种生物标志物是糖尿病患者CVD的潜在诊断和预后指标。
