Physiology Division, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Immunology Division, Department of Microbiology, College of Medicine, Taif University, Taif, Saudi Arabia; Immunology Division, Department of Zoology, Faculty of Science, Beni-Suef University, Beni-Suef, Egypt.
Biomed Pharmacother. 2018 May;101:287-292. doi: 10.1016/j.biopha.2018.02.103. Epub 2018 Feb 27.
Diabetes mellitus (DM) is a serious medical problem affecting millions of peoples worldwide, and has a great socio-economic impacts. Cytokines possess a pivotal role in modulation of immune reactions and disease pathogenesis. T-helper type 17 (Th17) cells, an important proinflammatory CD4 T cell subset secreting interleukin 17 (IL-17), has been embroiled in development of DM. There are recent evidences supporting a definitive role of Th17 cells in the etiology of type 1 diabetes (T1D). In addition, IL-17 has been shown to play a crucial role in inflammation, insulin resistance, and type 2 diabetes (T2D). Recently, small molecules which have been specified to block Th17 cells differentiation are considered as potential therapeutics for the disease. Anti-IL-17 neutralizing antibodies and/or antibodies targeting Th17 cells have been investigated to protect individuals at risk from disease development. In this review we aimed to shed light on the potential role of IL-17 and Th17 cells in both T1D and T2D pathogenesis and future therapeutic strategies.
糖尿病（DM）是一个严重的医学问题，影响着全世界数百万人的健康，对社会经济也有重大影响。细胞因子在调节免疫反应和疾病发病机制方面起着关键作用。辅助性 T 细胞 17（Th17）细胞是一种重要的促炎 CD4 T 细胞亚群，分泌白细胞介素 17（IL-17），它参与了 DM 的发生。有最近的证据表明 Th17 细胞在 1 型糖尿病（T1D）的发病机制中起决定性作用。此外，IL-17 已被证明在炎症、胰岛素抵抗和 2 型糖尿病（T2D）中起关键作用。最近，被指定用于阻断 Th17 细胞分化的小分子被认为是该疾病的潜在治疗方法。抗 IL-17 中和抗体和/或针对 Th17 细胞的抗体已被研究用于保护处于疾病发展风险中的个体。在这篇综述中，我们旨在阐明 IL-17 和 Th17 细胞在 T1D 和 T2D 发病机制中的潜在作用，以及未来的治疗策略。
