尼日利亚淋病奈瑟菌的质粒图谱及壮观霉素治疗淋病的疗效
Plasmid profile of Neisseria gonorrhoeae in Nigeria and efficacy of spectinomycin in treating gonorrhoea.
作者信息
Osoba A O, Johnston N A, Ogunbanjo B O, Ochei J
出版信息
Genitourin Med. 1987 Feb;63(1):1-5. doi: 10.1136/sti.63.1.1.
Abstract
The prevalence of penicillinase producing Neisseria gonorrhoeae (PPNG) strains has been steadily rising in Nigeria since 1979, and now about 80% of the strains of gonococci isolated in Ibadan are found to produce penicillinase. Spectinomycin has consequently become widely used in treating these infections. To ascertain the emergence of spectinomycin resistance, this study was undertaken to assess the in vivo susceptibilities of gonococcal strains to spectinomycin and other common antibiotics. Five hundred and twenty seven isolates were tested, of which 452 (85.5%) were PPNG strains. None of the strains were found to be resistant to 100 micrograms spectinomycin discs in vitro, whereas all 370 patients treated with the antibiotic were bacteriologically cured. Plasmid analysis shows that both "Asian" and "African" PPNG types are circulating in Nigeria. For the moment spectinomycin remains highly effective in treating gonococcal infections in west Africa.
摘要
自1979年以来，产青霉素酶的淋病奈瑟菌（PPNG）菌株在尼日利亚的流行率一直在稳步上升，现在在伊巴丹分离出的约80%的淋球菌菌株被发现能产生青霉素酶。因此，壮观霉素已被广泛用于治疗这些感染。为了确定壮观霉素耐药性的出现，本研究旨在评估淋球菌菌株对壮观霉素和其他常用抗生素的体内敏感性。测试了527株分离株，其中452株（85.5%）为PPNG菌株。在体外，没有发现菌株对100微克壮观霉素纸片耐药，而所有370例接受该抗生素治疗的患者均获得细菌学治愈。质粒分析表明，“亚洲”和“非洲”PPNG类型在尼日利亚均有传播。目前，壮观霉素在治疗西非的淋球菌感染方面仍然非常有效。
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