School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, PR China.
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, PR China.
Fitoterapia. 2018 Jun;127:257-262. doi: 10.1016/j.fitote.2018.02.032. Epub 2018 Mar 1.
Three new compounds, identified as (3S)-5-hydroxy-3-(2-hydroxybenzyl)-7-methoxychroman-4-one, oleracone C (1), 5-hydroxy-3-(2-hydroxybenzyl)-7-methoxy-4H-chromen-4-one, oleracone D (2), and 1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(2-hydroxyphenyl)propan-1-one, oleracone E (4), together with one new natural product, 5,7-dimethoxy-4-O-2'-cycloflavan (3) already known from synthesis, and two known compounds, (2S)-5,2'-dihydroxy-7-methoxyflavanone (5) and 2',4'-dihydroxy-4,6'-dimethoxychalcone (6) were isolated from the Portulaca oleracea L. for the first time. Their structures were elucidated using spectroscopic methods, including one- and two-dimensional nuclear magnetic resonance, high-resolution electrospray ionization time-of-flight mass spectrometry and circular dichroism spectrometry. Oleracone C (1), D (2) and E (4) presented scavenging activities in 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical quenching assay, with IC values of 23.27, 11.73, 13.17 μM, respectively and anticholinesterase activities with IC values ranging between 59.55 and 78.85 μM.
三种新化合物，分别鉴定为（3S）-5-羟基-3-（2-羟基苄基）-7-甲氧基色满-4-酮、欧芹素 C（1）、5-羟基-3-（2-羟基苄基）-7-甲氧基-4H-色满-4-酮、欧芹素 D（2）和 1-（2-羟基-4,6-二甲氧基苯基）-3-（2-羟基苯基）-1-丙酮、欧芹素 E（4），以及一种新的天然产物 5,7-二甲氧基-4-O-2'-环化黄酮（3），已经通过合成得到，以及两种已知化合物（2S）-5,2'-二羟基-7-甲氧基黄烷酮（5）和 2',4'-二羟基-4,6'-二甲氧基查尔酮（6），首次从马齿苋（Portulaca oleracea L.）中分离得到。它们的结构通过光谱方法阐明，包括一维和二维核磁共振、高分辨率电喷雾电离飞行时间质谱和圆二色光谱。欧芹素 C（1）、D（2）和 E（4）在 1,1-二苯基-2-苦基肼（DPPH）自由基清除测定中表现出清除活性，IC 值分别为 23.27、11.73 和 13.17 μM，以及乙酰胆碱酯酶活性，IC 值范围在 59.55 到 78.85 μM 之间。
