School of Pharmacy, Liaoning University of Traditional Chinese Medicine , Dalian , P.R. China.
School of The First Clinic, Liaoning University of Traditional Chinese Medicine , Shenyang , P.R. China.
Nat Prod Res. 2019 Dec;33(24):3500-3506. doi: 10.1080/14786419.2018.1484465. Epub 2018 Jun 13.
A new compound was identified as 3-(2-hydroxybenzyl)-5,7-dimethoxy-4-chromen-4-one (or 2'-dihydroxy-5,7-dimethoxy-homoisoflavone), oleracone F (), together with -hydroxy ethyl cinnamate () and 4-hydroxy-3-methoxy ethyl cinnamate () isolated from the L. for the first time and six known compounds, salicylic acid (), -carboline-3-carboxylic acid (), aurantiamide (), portulacanone A (), B () and C () Their structures were determined using spectroscopic methods, including one- and two-dimensional nuclear magnetic resonance and high-resolution electrospray ionization time-of-flight mass spectrometry. Notably, oleracone F () presented scavenging activity in 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical quenching assay, with IC value of 17.78 μM.
一种新的化合物被鉴定为 3-(2-羟苄基)-5,7-二甲氧基-4-色满-4-酮（或 2'-二羟基-5,7-二甲氧基-同型异黄酮），奥勒拉酮 F（），与从 L. 中分离出的 -羟基乙基肉桂酸（）和 4-羟基-3-甲氧基乙基肉桂酸（）一起，这是第一次分离出来，此外还有六种已知的化合物，水杨酸（），-咔啉-3-羧酸（），aurantiamide（），portulacanone A（），B（）和 C（）。它们的结构通过光谱方法确定，包括一维和二维核磁共振和高分辨率电喷雾电离飞行时间质谱。值得注意的是，奥勒拉酮 F（）在 1,1-二苯基-2-苦基肼（DPPH）自由基清除测定中表现出清除活性，IC 值为 17.78 μM。
