马齿苋中新的骨架类黄酮和新的木脂素及其活性。
A new skeleton flavonoid and a new lignan from Portulaca oleracea L. and their activities.
机构信息
School of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, PR China.
School of The First Clinic, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, PR China; Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, PR China.
出版信息
Fitoterapia. 2021 Sep;153:104993. doi: 10.1016/j.fitote.2021.104993. Epub 2021 Jul 17.
A new skeleton flavonoid, identified as (5aR)-10-hydroxy-8-methoxy-5aH,11H-chromeno[2,3-b]chromen-11-one (1), named oleracone G, and a new lignan, confirmed as 8-(4-hydroxy-3-methoxyphenyl)-3-methoxynaphthalen-2-ol (2), named oleralignan B, were isolated from Portulaca oleracea L., and the structures of them were determined using spectroscopic methods including UV, IR, 1D NMR, 2D NMR, and UHPLC-ESI-QTOF/MS. In addition, compounds 1-2 were applied to investigate the anti-inflammatory activities on lipopolysaccharide-stimulated macrophages and scavenging effects in 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical. The results showed that the two compounds at 10 μM and 20 μM could dose-dependently decrease the secretion of interleukin 1β in RAW 264.7 cells by enzyme-linked immunosorbent assay, moreover, presented remarkable antioxidant activities with IC values of 27.57, 20.12 μM, respectively.
从马齿苋（Portulaca oleracea L.）中分离得到一个新骨架黄酮类化合物，鉴定为（5aR）-10-羟基-8-甲氧基-5aH,11H-色烯并[2,3-b]色烯-11-酮（1），命名为欧芹素 G，和一个新的木脂素，确认为 8-(4-羟基-3-甲氧基苯基)-3-甲氧基萘-2-醇（2），命名为欧芹烷 B。采用 UV、IR、1D NMR、2D NMR 和 UHPLC-ESI-QTOF/MS 等光谱方法确定了它们的结构。此外，将化合物 1-2 应用于研究对脂多糖刺激的巨噬细胞的抗炎活性和 1,1-二苯基-2-苦基肼（DPPH）自由基的清除作用。结果表明，这两种化合物在 10 μM 和 20 μM 时可以通过酶联免疫吸附试验剂量依赖性地降低 RAW 264.7 细胞中白细胞介素 1β的分泌，而且具有显著的抗氧化活性，IC 值分别为 27.57 μM 和 20.12 μM。
Zotero 插件