Leigh R J, Newman S A, Folstein S E, Lasker A G, Jensen B A
Neurology. 1983 Oct;33(10):1268-75. doi: 10.1212/wnl.33.10.1268.
We studied eye movements in 50 patients with Huntington's disease. Fixation was impaired in 73% of patients; such individuals had difficulty in suppressing saccades toward novel visual stimuli. Impaired initiation of saccades was manifest by increased reaction time (89%) and inability to make a saccade without head movement (89%) or blink (35%). Saccades and quick phases of nystagmus were slowed in 62%. Smooth pursuit was abnormal in 60%, and vergence in 33%. The vestibulo-ocular reflex and the ability to hold eccentric gaze were preserved even late in the disease.
我们研究了50例亨廷顿舞蹈症患者的眼球运动情况。73%的患者存在注视障碍；这些个体难以抑制对新视觉刺激的扫视。扫视启动受损表现为反应时间增加（89%），以及无法在不伴有头部运动（89%）或眨眼（35%）的情况下进行扫视。62%的患者扫视和眼球震颤的快相减慢。60%的患者平稳跟踪异常，33%的患者辐辏异常。即使在疾病晚期，前庭眼反射和保持偏中心注视的能力仍得以保留。
