应对非NASH型NAFLD的负担
Managing the Burden of Non-NASH NAFLD.
作者信息
Danford Christopher J, Sanchez Jorge E, Corey Kathleen E
机构信息
Division of Gastroenterology and Hepatology, Beth Israel Deaconness Medical Center, Boston, MA, USA.
Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
出版信息
Curr Hepatol Rep. 2017 Dec;16(4):326-334. doi: 10.1007/s11901-017-0371-9. Epub 2017 Oct 27.
PURPOSE OF REVIEW
The purpose of this review article is to raise awareness of the significance of steatosis that exist within the spectrum of nonalcoholic fatty liver disease (NAFLD). While the impact of nonalcoholic steatohepatitis (NASH), and its potential for histologic progression to cirrhosis and hepatocellular carcinoma is widely appreciated, the impact of non-NASH NAFLD (steatosis) on morbidity and mortality is less well recognized.
RECENT FINDINGS
NAFLD is a spectrum of hepatic pathology with a rising prevalence worldwide. Steatosis without fibrosis carries a low risk of progression to cirrhosis but likely confers an increased risk of diabetes mellitus and cardiovascular disease.
SUMMARY
About a quarter of the world population is affected by NAFLD. NAFLD represents a burden to affected individuals, economics of the health care system and contributes significantly to morbidity and mortality worldwide. An increased level of awareness and knowledge about risk factors and diagnostic strategies is needed to identify patients affected with disease.
综述目的
本文综述的目的是提高对非酒精性脂肪性肝病（NAFLD）范围内存在的脂肪变性重要性的认识。虽然非酒精性脂肪性肝炎（NASH）的影响及其组织学进展为肝硬化和肝细胞癌的可能性已得到广泛认可，但非NASH的NAFLD（脂肪变性）对发病率和死亡率的影响却鲜为人知。
最新发现
NAFLD是一种肝脏病理谱，在全球范围内患病率不断上升。无纤维化的脂肪变性进展为肝硬化的风险较低，但可能会增加患糖尿病和心血管疾病的风险。
总结
世界约四分之一的人口受NAFLD影响。NAFLD给受影响的个体、医疗保健系统的经济带来负担，并在全球范围内对发病率和死亡率有重大影响。需要提高对危险因素和诊断策略的认识和了解，以识别受该疾病影响的患者。
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