Antonov I B, Kozlov K L, Pal'tseva E M, Polyakova O V, Lin'kova N S
St. Petersburg Institute of Bioregulation and Gerontology, St. Petersburg, Russia.
B. V. Petrovsky Russian Surgery Research Center, Moscow, Russia.
Bull Exp Biol Med. 2018 Mar;164(4):550-553. doi: 10.1007/s10517-018-4030-0. Epub 2018 Mar 5.
We studied the expression of MMP-2, MMP-9, and inhibitor TIMP-1 in myocardial autopsy samples from subjects of different age and in cardiomyocyte cultures in the norm and in dilated cardiomyopathy. In autopsy samples of normal myocardium and in cardiomyocyte cultures, expression of molecules involved in extracellular matrix remodeling did not change during aging. In dilation cardiomyopathy, expression of MMP-2, MMP-9, and TIMP-1 and their ratios in autopsy material and in cultures was elevated by 1.5-9 times. Remodeling of extracellular matrix plays an important role in the pathogenesis of dilated cardiomyopathy. MMP-2, MMP-9, and their inhibitor TIMP-1 and the MMP/TIMP ratios can be regarded as promising predictors of dilated cardiomyopathy and used for evaluation of the effectiveness of treatment of this conditions in patients of different ages.
我们研究了不同年龄受试者心肌尸检样本以及正常和扩张型心肌病心肌细胞培养物中基质金属蛋白酶-2（MMP-2）、基质金属蛋白酶-9（MMP-9）和抑制剂金属蛋白酶组织抑制因子-1（TIMP-1）的表达情况。在正常心肌尸检样本和心肌细胞培养物中，参与细胞外基质重塑的分子表达在衰老过程中并未改变。在扩张型心肌病中，尸检材料和培养物中MMP-2、MMP-9和TIMP-1的表达及其比值升高了1.5至9倍。细胞外基质重塑在扩张型心肌病的发病机制中起重要作用。MMP-2、MMP-9及其抑制剂TIMP-1以及MMP/TIMP比值可被视为扩张型心肌病的有前景的预测指标，并用于评估不同年龄患者该疾病的治疗效果。
