Verpaalen Valentine D, Baltzer Wendy I, Smith-Ostrin Sarah, Warnock Jennifer J, Stang Bernadette, Ruaux Craig G
J Am Vet Med Assoc. 2018 Mar 15;252(6):701-709. doi: 10.2460/javma.252.6.701.
OBJECTIVE To determine the effects of an omega-3 fatty acid and protein-enriched diet, physical rehabilitation, or both on radiographic findings and markers of synovial inflammation in dogs following tibial plateau leveling osteotomy and arthroscopic surgery for treatment of cranial cruciate ligament disease. DESIGN Randomized, prospective clinical trial. ANIMALS 48 dogs with unilateral cranial cruciate ligament disease. PROCEDURES Dogs were randomly assigned to receive a dry omega-3 fatty acid and protein-enriched dog food formulated to support joint health (test food [TF]), a dry food formulated for adult canine maintenance (control food [CF]), TF plus rehabilitation, or CF plus rehabilitation after surgery. Synovial fluid prostaglandin (PG) E and interleukin-1β concentrations, radiographic osteoarthritis scores, osteotomy site healing, and patellar ligament thickness were assessed at predetermined time points up to 6 months after surgery. RESULTS Dogs that received CF had significantly higher PGE concentrations over time following surgery than did dogs that received TF, regardless of rehabilitation status. Synovial fluid interleukin-1β concentrations did not change over time in any groups. Diet and rehabilitation were both associated with osteoarthritis scores, with significantly lower scores over time for dogs that received TF versus CF and for dogs that underwent rehabilitation versus those that did not. Proportions of dogs with complete osteotomy healing 8 and 24 weeks after surgery were significantly lower for dogs that received TF than for dogs that received CF, regardless of rehabilitation status. CONCLUSIONS AND CLINICAL RELEVANCE Results suggested that feeding the TF can result in lower synovial fluid PGE concentrations and that both the TF and rehabilitation can reduce progression of osteoarthritis in the 6 months following tibial plateau leveling osteotomy; clinical relevance of slower osteotomy healing in dogs fed the TF was unclear.
目的 确定富含ω-3脂肪酸和蛋白质的饮食、物理康复或两者对患有胫骨平台水平截骨术和关节镜手术治疗颅交叉韧带疾病的犬的影像学表现和滑膜炎症标志物的影响。 设计 随机、前瞻性临床试验。 动物 48只单侧颅交叉韧带疾病的犬。 程序 将犬随机分配接受为支持关节健康而配制的富含ω-3脂肪酸和蛋白质的干狗粮（试验食物[TF]）、为成年犬维持配制的干狗粮（对照食物[CF]）、TF加康复治疗，或手术后CF加康复治疗。在手术后长达6个月的预定时间点评估滑液前列腺素（PG）E和白细胞介素-1β浓度、影像学骨关节炎评分、截骨部位愈合情况和髌韧带厚度。 结果 无论康复状态如何，接受CF的犬在手术后随着时间推移PGE浓度显著高于接受TF的犬。任何组的滑液白细胞介素-1β浓度随时间均无变化。饮食和康复治疗均与骨关节炎评分相关，接受TF的犬与接受CF的犬相比，以及接受康复治疗的犬与未接受康复治疗的犬相比，随着时间推移评分显著更低。无论康复状态如何，接受TF的犬在手术后8周和24周截骨完全愈合的比例显著低于接受CF的犬。 结论和临床意义 结果表明，喂食TF可导致滑液PGE浓度降低，并且TF和康复治疗均可在胫骨平台水平截骨术后6个月内减少骨关节炎的进展；喂食TF的犬截骨愈合较慢的临床意义尚不清楚。
