Baltzer Wendy I, Smith-Ostrin Sarah, Warnock Jennifer J, Ruaux Craig G
J Am Vet Med Assoc. 2018 Mar 15;252(6):686-700. doi: 10.2460/javma.252.6.686.
OBJECTIVE To assess clinical effects of an omega-3 fatty acid and protein-enriched diet, physical rehabilitation, or both in dogs following tibial plateau leveling osteotomy (TPLO) and arthroscopic surgery for cranial cruciate ligament (CCL) disease. DESIGN Randomized, prospective clinical trial. ANIMALS 48 dogs with unilateral CCL disease. PROCEDURES Dogs were randomly assigned to receive a dry omega-3 fatty acid and protein-enriched dog food formulated to support joint health (test food [TF]), a dry food formulated for maintenance of adult dogs (control food [CF]), TF plus rehabilitation (TF-R), or CF plus rehabilitation (CF-R). Data collected over 6 months included body weight, body condition score, ground reaction force data, tibial plateau angle, limb circumference measurements, subjective pain and lameness scores assigned by surgeons and dog owners, and daily activity measured by accelerometry. RESULTS Peak vertical force and vertical impulse were greater after surgery for dogs in the TF groups than in the CF groups; peak vertical force was greater after surgery in dogs that underwent rehabilitation than in those that did not. Owner scores indicated lower frequencies of lameness and signs of pain during some activities for the TF group, compared with other groups, and for the TF-R and CF-R groups, compared with the CF group. Sedentary time decreased and time spent in light-to-moderate or vigorous activity increased in all groups over time. Rehabilitation was significantly associated with greater time spent in light-to-moderate activity, regardless of diet. CONCLUSIONS AND CLINICAL RELEVANCE Feeding the TF and providing physical rehabilitation during the first 6 months after TPLO were associated with improvements in some indices of clinical outcome and function in dogs. Significant interactions between time and some outcome variables were observed, indicating further research is warranted.
目的 评估富含ω-3脂肪酸和蛋白质的饮食、物理康复或两者结合对胫骨平台水平截骨术（TPLO）和关节镜手术治疗颅交叉韧带（CCL）疾病后的犬的临床效果。 设计 随机、前瞻性临床试验。 动物 48只单侧CCL疾病的犬。 程序 将犬随机分配接受为支持关节健康而配制的富含ω-3脂肪酸和蛋白质的干狗粮（试验食品[TF]）、为成年犬维持体重而配制的干狗粮（对照食品[CF]）、TF加康复治疗（TF-R）或CF加康复治疗（CF-R）。在6个月内收集的数据包括体重、身体状况评分、地面反作用力数据、胫骨平台角度、肢体周长测量、外科医生和犬主分配的主观疼痛和跛行评分，以及通过加速度计测量的日常活动量。 结果 TF组犬术后的峰值垂直力和垂直冲量高于CF组；接受康复治疗的犬术后的峰值垂直力高于未接受康复治疗的犬。犬主评分表明，与其他组相比，TF组在某些活动中的跛行频率和疼痛迹象较低，与CF组相比，TF-R组和CF-R组也是如此。随着时间的推移，所有组的久坐时间减少，轻度至中度或剧烈活动时间增加。无论饮食如何，康复治疗与更多时间花在轻度至中度活动上显著相关。 结论和临床意义 在TPLO后的前6个月喂养TF并提供物理康复治疗与犬的一些临床结果和功能指标的改善有关。观察到时间与一些结果变量之间存在显著相互作用，表明有必要进行进一步研究。
