Division of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University Basel, Basel, Switzerland.
Department of Medical Microbiology, Centre for Infectious Diseases, Leiden University Medical Center, Leiden, The Netherlands.
Clin Microbiol Infect. 2018 Oct;24(10):1051-1054. doi: 10.1016/j.cmi.2018.02.020. Epub 2018 Mar 2.
Clostridium difficile infection (CDI) is the most important infective cause of healthcare-associated diarrhoea in high income countries and one of the most important healthcare-associated pathogens in both Europe and the United States. It is associated with high morbidity and mortality resulting in both societal and financial burden. A significant proportion of this burden is potentially preventable by a combination of targeted infection prevention and control measures and antimicrobial stewardship. The aim of this guidance document is to provide an update on recommendations for prevention of CDI in acute care settings to provide guidance to those responsible for institutional infection prevention and control programmes.
An expert group was set up by the European society of clinical microbiology and infectious diseases (ESCMID) Study Group for C. difficile (ESGCD), which performed a systematic review of the literature on prevention of CDI in adults hospitalized in acute care settings and derived respective recommendations according to the GRADE approach. Recommendations are stratified for both outbreak and endemic settings.
This guidance document provides thirty-six statements on strategies to prevent CDI in acute care settings, including 18 strong recommendations. No recommendation was provided for three questions.
艰难梭菌感染（CDI）是高收入国家中最重要的与医疗保健相关的腹泻感染原因之一，也是欧洲和美国最重要的与医疗保健相关的病原体之一。它与高发病率和死亡率相关，导致社会和经济负担。通过组合目标感染预防和控制措施以及抗菌药物管理，可以在很大程度上预防这种负担。本指南文件旨在提供有关急性护理环境中预防 CDI 的建议更新，为负责机构感染预防和控制计划的人员提供指导。
欧洲临床微生物学和传染病学会（ESCMID）艰难梭菌研究组（ESGCD）成立了一个专家组，对成人在急性护理环境中住院预防 CDI 的文献进行了系统审查，并根据 GRADE 方法得出了各自的建议。建议根据暴发和流行情况进行分层。
本指南文件提供了 36 条关于急性护理环境中预防 CDI 的策略，包括 18 条强烈建议。对三个问题没有提供建议。
