抗菌药物对急性钩端螺旋体病炎症细胞因子的影响。
Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis.
机构信息
Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo, Sri Lanka
Department of Immunology, Medical Research Institute, Colombo, Sri Lanka.
出版信息
Antimicrob Agents Chemother. 2018 Apr 26;62(5). doi: 10.1128/AAC.02312-17. Print 2018 May.
Abstract
The aim of this study was to assess the inflammatory cytokine response and possible association with antimicrobial treatment with penicillin, ceftriaxone, and doxycycline in acute leptospirosis. In the early acute stage, interleukin-10 (IL-10) levels were higher in mild cases than in severe cases ( = 0.01). IL-6 and IL-8 levels were low in patients who received >5 antimicrobial doses ( < 0.01). IL-8 levels were negatively correlated with the number of ceftriaxone doses administered ( = -0.315; = 0.031). Further studies are needed to evaluate the possible downregulation of proinflammatory cytokines by ceftriaxone in leptospirosis.
摘要
本研究旨在评估急性钩端螺旋体病中炎症细胞因子的反应以及与青霉素、头孢曲松和强力霉素抗菌治疗的可能关联。在早期急性阶段，轻症患者的白细胞介素-10（IL-10）水平高于重症患者（ = 0.01）。接受 >5 剂抗菌药物治疗的患者的白细胞介素-6（IL-6）和白细胞介素-8（IL-8）水平较低（<0.01）。IL-8 水平与头孢曲松给药次数呈负相关（ = -0.315； = 0.031）。需要进一步的研究来评估头孢曲松在钩端螺旋体病中可能下调促炎细胞因子的作用。
相似文献
1
Effect of Antimicrobial Agents on Inflammatory Cytokines in Acute Leptospirosis.抗菌药物对急性钩端螺旋体病炎症细胞因子的影响。
Antimicrob Agents Chemother. 2018 Apr 26;62(5). doi: 10.1128/AAC.02312-17. Print 2018 May.
2
Cytokine profile of patients with leptospirosis in Sabah, Malaysia.马来西亚沙巴州钩端螺旋体病患者的细胞因子谱
Med J Malaysia. 2018 Apr;73(2):106-109.
3
Cytokine levels as biomarkers for leptospirosis patients.细胞因子水平作为钩端螺旋体病患者的生物标志物
Cytokine. 2016 Sep;85:80-2. doi: 10.1016/j.cyto.2016.06.007. Epub 2016 Jun 10.
4
Raised levels of Il-6, Il-17a, and Il-22 in fatal leptospirosis.致死性钩端螺旋体病中白细胞介素-6、白细胞介素-17a 和白细胞介素-22 水平升高。
Eur J Clin Microbiol Infect Dis. 2019 Dec;38(12):2349-2353. doi: 10.1007/s10096-019-03699-5. Epub 2019 Sep 16.
5
Serum TNF-α, sTNFR1, IL-6, IL-8 and IL-10 levels in Weil's syndrome.血清 TNF-α、sTNFR1、IL-6、IL-8 和 IL-10 在韦尔氏综合征中的水平。
Cytokine. 2011 May;54(2):117-20. doi: 10.1016/j.cyto.2011.01.014. Epub 2011 Feb 12.
6
Serum procalcitonin and proinflammatory cytokines in a patient with acute severe leptospirosis.急性重症钩端螺旋体病患者的血清降钙素原及促炎细胞因子
Scand J Infect Dis. 2000;32(1):104-5. doi: 10.1080/00365540050164362.
7
Elevated levels of IL-8 in fatal leptospirosis.致命性钩端螺旋体病患者白细胞介素-8 水平升高。
Pathog Glob Health. 2020 Mar;114(2):99-103. doi: 10.1080/20477724.2020.1724356. Epub 2020 Feb 5.
8
Contributing role of TNF, IL-10, sTNFR1 and TNF gene polymorphisms in disease severity of leptospirosis.TNF、IL-10、sTNFR1 和 TNF 基因多态性在钩端螺旋体病疾病严重程度中的作用。
Med Microbiol Immunol. 2021 Aug;210(4):211-219. doi: 10.1007/s00430-021-00714-5. Epub 2021 Jun 23.
9
Plasma cytokine levels predict mortality in patients with acute renal failure.血浆细胞因子水平可预测急性肾衰竭患者的死亡率。
Kidney Int. 2004 Apr;65(4):1357-65. doi: 10.1111/j.1523-1755.2004.00512.x.
10
Cytokines in human leptospirosis.人类钩端螺旋体病中的细胞因子
Trans R Soc Trop Med Hyg. 2015 Dec;109(12):749-54. doi: 10.1093/trstmh/trv095.
引用本文的文献
1
Predictors of severe leptospirosis: a review.重症钩端螺旋体病的预测因素：综述
Eur J Med Res. 2025 Jun 2;30(1):445. doi: 10.1186/s40001-025-02518-2.
2
Contributing role of TNF, IL-10, sTNFR1 and TNF gene polymorphisms in disease severity of leptospirosis.TNF、IL-10、sTNFR1 和 TNF 基因多态性在钩端螺旋体病疾病严重程度中的作用。
Med Microbiol Immunol. 2021 Aug;210(4):211-219. doi: 10.1007/s00430-021-00714-5. Epub 2021 Jun 23.
3
Cytokine response in human leptospirosis with different clinical outcomes: a systematic review.人类不同临床结局钩端螺旋体病的细胞因子反应：系统综述。
BMC Infect Dis. 2020 Apr 7;20(1):268. doi: 10.1186/s12879-020-04986-9.
4
Raised levels of Il-6, Il-17a, and Il-22 in fatal leptospirosis.致死性钩端螺旋体病中白细胞介素-6、白细胞介素-17a 和白细胞介素-22 水平升高。
Eur J Clin Microbiol Infect Dis. 2019 Dec;38(12):2349-2353. doi: 10.1007/s10096-019-03699-5. Epub 2019 Sep 16.
本文引用的文献
1
Protein Carbonyl as a Biomarker of Oxidative Stress in Severe Leptospirosis, and Its Usefulness in Differentiating Leptospirosis from Dengue Infections.蛋白质羰基作为重症钩端螺旋体病氧化应激的生物标志物及其在区分钩端螺旋体病与登革热感染中的作用
PLoS One. 2016 Jun 9;11(6):e0156085. doi: 10.1371/journal.pone.0156085. eCollection 2016.
2
Cytokines in human leptospirosis.人类钩端螺旋体病中的细胞因子
Trans R Soc Trop Med Hyg. 2015 Dec;109(12):749-54. doi: 10.1093/trstmh/trv095.
3
Cytokine response signatures in disease progression and development of severe clinical outcomes for leptospirosis.细胞因子反应特征与钩端螺旋体病的疾病进展和严重临床结局的发生。
PLoS Negl Trop Dis. 2013 Sep 19;7(9):e2457. doi: 10.1371/journal.pntd.0002457. eCollection 2013.
4
Association of high plasma TNF-alpha levels and TNF-alpha/IL-10 ratios with TNF2 allele in severe P. falciparum malaria patients in Sri Lanka.在斯里兰卡严重恶性疟患者中，高血浆 TNF-α水平和 TNF-α/IL-10 比值与 TNF2 等位基因相关联。
Pathog Glob Health. 2013 Jan;107(1):21-9. doi: 10.1179/2047773212Y.0000000069.
5
Prerequisites for cytokine measurements in clinical trials with multiplex immunoassays.用于多重免疫分析临床试验中细胞因子测量的前提条件。
BMC Immunol. 2009 Sep 28;10:52. doi: 10.1186/1471-2172-10-52.
6
Soluble ST2 levels are associated with bleeding in patients with severe Leptospirosis.可溶性 ST2 水平与严重钩端螺旋体病患者的出血有关。
PLoS Negl Trop Dis. 2009 Jun 2;3(6):e453. doi: 10.1371/journal.pntd.0000453.
7
Use of ceftriaxone in patients with severe leptospirosis.头孢曲松在重症钩端螺旋体病患者中的应用。
Int J Antimicrob Agents. 2006 Sep;28(3):259-61. doi: 10.1016/j.ijantimicag.2006.04.011. Epub 2006 Aug 7.
8
Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines.强力霉素具有抗炎作用，可抑制葡萄球菌外毒素诱导的细胞因子和趋化因子。
Antimicrob Agents Chemother. 2003 Nov;47(11):3630-3. doi: 10.1128/AAC.47.11.3630-3633.2003.
9
The effect of three broad-spectrum antimicrobials on mononuclear cell responses to encapsulated bacteria: evidence for down-regulation of cytokine mRNA transcription by trovafloxacin.三种广谱抗菌药物对单核细胞对包膜细菌反应的影响：曲伐沙星下调细胞因子mRNA转录的证据。
J Antimicrob Chemother. 2000 Dec;46(6):921-9. doi: 10.1093/jac/46.6.921.
Zotero 插件