Centre of Medical Laboratory Technology, Faculty of Health Sciences, Universiti Teknologi MARA Cawangan Selangor, Bandar Puncak Alam, Malaysia.
Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, UPM, Serdang, Malaysia.
Pathog Glob Health. 2020 Mar;114(2):99-103. doi: 10.1080/20477724.2020.1724356. Epub 2020 Feb 5.
Leptospirosis causes a wide range of clinical outcomes, including organ failure and death. Early treatment significantly increases the chances of cure. Interleukin-8 (IL-8) is a chemoattractant cytokine for neutrophil and is associated with multiple organ failure. Research has indicated IL-8 to be raised in severe and fatal cases of leptospirosis, but its suitability as a prognostic biomarker has yet to be confirmed. This study aimed to evaluate the significance of IL-8 with the clinical outcomes of leptospirosis patients. Plasma IL-8 was measured in fifty-two samples from hospitalized patients and nineteen healthy controls. The comparisons were made between mild, severe-survived and fatal groups identified by clinical or laboratory findings. IL-8 was significantly higher in fatal (p = 0.01) compared to mild cases. IL-8 was also significantly higher in fatal (p = 0.02) when compared to survived cases of leptospirosis. IL-8 levels in the plasma of fatal leptospirosis cases were significantly elevated compared to survived cases and may serve as a potential prognostic biomarker in determining the possible outcome of leptospirosis patients.
钩端螺旋体病可引起多种临床结局，包括器官衰竭和死亡。早期治疗可显著提高治愈机会。白细胞介素-8 (IL-8) 是一种趋化因子，可吸引中性粒细胞，并与多器官衰竭有关。研究表明，IL-8 在严重和致命的钩端螺旋体病病例中升高，但尚未证实其作为预后生物标志物的适用性。本研究旨在评估 IL-8 与钩端螺旋体病患者临床结局的关系。测量了 52 名住院患者和 19 名健康对照者的血浆 IL-8。通过临床或实验室发现，对轻度、重度存活和致命组进行了比较。与轻度病例相比，致命病例的 IL-8 显著升高（p=0.01）。与存活的钩端螺旋体病病例相比，致命病例的 IL-8 也显著升高（p=0.02）。与存活的钩端螺旋体病病例相比，致命钩端螺旋体病病例的血浆 IL-8 水平显著升高，可能成为预测钩端螺旋体病患者预后的潜在生物标志物。
