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[2017年德国骨科学与风湿病学会亚瑟·维克奖]

[Arthur Vick Prize 2017 of the German Society of Orthopaedic Rheumatology].

作者信息

Bause L, Niemeier A, Krenn V

机构信息

Klinik für Rheumaorthopädie, St. Josef-Stift Sendenhorst, Sendenhorst, Deutschland.

Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland.

出版信息

Z Rheumatol. 2018 Mar;77(2):168-174. doi: 10.1007/s00393-018-0433-6.

Abstract

The German Society of Orthopaedic Rheumatology (DGORh) honored Prof. Dr. med. Veit Krenn (MVZ-ZHZMD-Trier) with the Arthur Vick Prize 2017. With this award, scientific results with high impact on the diagnosis, therapy and pathogenetic understanding of rheumatic diseases are honored. In cooperation with pathologists and colleagues from various clinical disciplines Prof. Dr. med. Veit Krenn developed several histopathologic scoring systems which contribute to the diagnosis and pathogenetic understanding of degenerative and rheumatic diseases. These scores include the synovitis score, the meniscal degeneration score, the classification of periprosthetic tissues (SLIM classification), the arthrofibrosis score, the particle score and the CD15 focus score. Of highest relevance for orthopedic rheumatology is the synovitis score which is a semiquantitative score for evaluating immunological and inflammatory changes of synovitis in a graded manner. Based on this score, it is possible to divide results into low-grade synovitis and high-grade synovitis: a synovitis score of 1-4 is called low-grade synovitis and occurs for example in association with osteoarthritis (OA), post-trauma, with meniscal lesions and hemochromatosis. A synovitis score of 5-9 is called high-grade synovitis, e.g. rheumatoid arthritis, psoriatic arthritis, Lyme arthritis, postinfection and reactive arthritis as well as peripheral arthritis with Bechterew's disease (sensitivity 61.7%, specificity 96.1%). The first publication (2002) and an associated subsequent publication (2006) of the synovitis score has led to national and international acceptance of this score as the standard for histopathological assessment of synovitis. The synovitis score provides a diagnostic, standardized and reproducible histopathological evaluation method for joint diseases, particularly when this score is applied in the context with the joint pathology algorithm.

摘要

德国骨科学与风湿病学会(DGORh)授予医学博士维特·克伦教授(特里尔MVZ-ZHZMD)2017年亚瑟·维克奖。该奖项旨在表彰对风湿病的诊断、治疗和发病机制理解有重大影响的科研成果。维特·克伦医学博士与病理学家及各临床学科的同事合作,开发了多种组织病理学评分系统,这些系统有助于对退行性疾病和风湿性疾病进行诊断和发病机制的理解。这些评分包括滑膜炎评分、半月板退变评分、假体周围组织分类(SLIM分类)、关节纤维化评分、颗粒评分和CD15焦点评分。对骨科风湿病最具相关性的是滑膜炎评分,它是一种半定量评分,用于分级评估滑膜炎的免疫和炎症变化。基于该评分,可以将结果分为低度滑膜炎和高度滑膜炎:滑膜炎评分为1 - 4分称为低度滑膜炎,例如与骨关节炎(OA)、创伤后、半月板损伤和血色素沉着症相关。滑膜炎评分为5 - 9分称为高度滑膜炎,例如类风湿关节炎、银屑病关节炎、莱姆关节炎、感染后和反应性关节炎以及伴有贝赫切特病的外周关节炎(敏感性61.7%,特异性96.1%)。滑膜炎评分的首次发表(2002年)及随后的相关发表(2006年)已使该评分在国内和国际上被接受为滑膜炎组织病理学评估的标准。滑膜炎评分为关节疾病提供了一种诊断性、标准化且可重复的组织病理学评估方法,特别是当该评分与关节病理学算法结合应用时。

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