Blumenkranz M S, Hartzer M K, Hajek A S
Arch Ophthalmol. 1987 Mar;105(3):396-9. doi: 10.1001/archopht.1987.01060030116039.
We confirm the potent antiproliferative effects of the fluoropyrimidines on cellular proliferation in vitro in three different nonmalignant cell types. All fluoropyrimidines tested, except for fluorocytosine, decrease proliferation of human dermal fibroblasts, bovine aortic vascular endothelial cells, and human retinal pigment epithelial cells in vitro. Fluorouridine, an intracellular metabolite of fluorouracil, is nearly 100-fold more potent than fluorouracil and its deoxymetabolite. Human dermal fibroblasts are more sensitive to the inhibitory effects of deoxymetabolites than the cells of either human retinal pigment epithelium or bovine aortic vascular endothelium. Fluorouridine and other fluoropyrimidines may prove to be valuable second-generation drugs in the treatment of intraocular proliferative disorders.
我们证实了氟嘧啶在体外对三种不同非恶性细胞类型的细胞增殖具有强效抗增殖作用。除氟胞嘧啶外，所有测试的氟嘧啶均可在体外降低人皮肤成纤维细胞、牛主动脉血管内皮细胞和人视网膜色素上皮细胞的增殖。氟尿苷是氟尿嘧啶的细胞内代谢产物，其效力比氟尿嘧啶及其脱氧代谢产物强近100倍。人皮肤成纤维细胞比人视网膜色素上皮细胞或牛主动脉血管内皮细胞对脱氧代谢产物的抑制作用更敏感。氟尿苷和其他氟嘧啶可能被证明是治疗眼内增殖性疾病的有价值的第二代药物。
