Curvo Eduardo Ov, Ferreira Roberto R, Madeira Fabiana S, Alves Gabriel F, Chambela Mayara C, Mendes Veronica G, Sangenis Luiz Henrique C, Waghabi Mariana C, Saraiva Roberto M
Fundação Oswaldo Cruz-Fiocruz, Instituto Nacional de Infectologia Evandro Chagas, Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Rio de Janeiro, RJ, Brasil.
Mem Inst Oswaldo Cruz. 2018 Feb 19;113(4):e170440. doi: 10.1590/0074-02760170440.
Transforming growth factor β1 (TGF-β1) and tumour necrosis factor (TNF) have been implicated in Chagas disease pathophysiology and may correlate with left ventricular (LV) function.
We determined whether TGF-β1 and TNF serum levels correlate with LV systolic and diastolic functions and brain natriuretic peptide (BNP) serum levels in chronic Chagas disease.
This cross-sectional study included 152 patients with Chagas disease (43% men; 57 ± 12 years old), classified as 53 patients with indeterminate form and 99 patients with cardiac form (stage A: 24, stage B: 25, stage C: 44, stage D: 6). TGF-β1, TNF, and BNP were determined by enzyme-linked immunosorbent assay ELISA. Echocardiogram was used to determine left atrial and LV diameters, as well as LV ejection fraction and diastolic function.
TGF-b1 serum levels were lower in stages B, C, and D, while TNF serum levels were higher in stages C and D of the cardiac form. TGF-β1 presented a weak correlation with LV diastolic function and LV ejection fraction. TNF presented a weak correlation with left atrial and LV diameters and LV ejection fraction.
TNF is increased, while TGF-β1 is decreased in the cardiac form of chronic Chagas disease. TNF and TGF-β1 serum levels present a weak correlation with LV systolic and diastolic function in Chagas disease patients.
转化生长因子β1（TGF-β1）和肿瘤坏死因子（TNF）与恰加斯病的病理生理过程有关，可能与左心室（LV）功能相关。
我们确定了在慢性恰加斯病中，TGF-β1和TNF血清水平是否与左心室收缩和舒张功能以及脑钠肽（BNP）血清水平相关。
这项横断面研究纳入了152例恰加斯病患者（男性占43%；年龄57±12岁），分为53例不确定型患者和99例心脏型患者（A期：24例，B期：25例，C期：44例，D期：6例）。通过酶联免疫吸附测定（ELISA）法测定TGF-β1、TNF和BNP。使用超声心动图确定左心房和左心室直径，以及左心室射血分数和舒张功能。
在B期、C期和D期，TGF-β1血清水平较低，而在心脏型的C期和D期，TNF血清水平较高。TGF-β1与左心室舒张功能和左心室射血分数呈弱相关。TNF与左心房和左心室直径以及左心室射血分数呈弱相关。
在慢性恰加斯病的心脏型中，TNF升高，而TGF-β1降低。在恰加斯病患者中，TNF和TGF-β1血清水平与左心室收缩和舒张功能呈弱相关关系。
