PWMScan：一种快速的工具，用于扫描具有位置特异性权重矩阵的整个基因组。
PWMScan: a fast tool for scanning entire genomes with a position-specific weight matrix.
机构信息
The Swiss Institute for Experimental Cancer Research (ISREC), Swiss Federal Institute of Technology Lausanne (EPFL).
Swiss Institute of Bioinformatics, Lausanne, Switzerland.
出版信息
Bioinformatics. 2018 Jul 15;34(14):2483-2484. doi: 10.1093/bioinformatics/bty127.
SUMMARY
Transcription factors regulate gene expression by binding to specific short DNA sequences of 5-20 bp to regulate the rate of transcription of genetic information from DNA to messenger RNA. We present PWMScan, a fast web-based tool to scan server-resident genomes for matches to a user-supplied PWM or transcription factor binding site model from a public database.
AVAILABILITY AND IMPLEMENTATION
The web server and source code are available at http://ccg.vital-it.ch/pwmscan and https://sourceforge.net/projects/pwmscan, respectively.
SUPPLEMENTARY INFORMATION
Supplementary data are available at Bioinformatics online.
摘要
转录因子通过与 5-20bp 的特定短 DNA 序列结合来调节基因表达，从而调节从 DNA 到信使 RNA 的遗传信息转录速度。我们介绍了 PWMScan，这是一种快速的基于网络的工具，用于在服务器驻留的基因组中搜索与用户提供的 PWM 或来自公共数据库的转录因子结合位点模型的匹配。
可用性和实现
网络服务器和源代码分别可在 http://ccg.vital-it.ch/pwmscan 和 https://sourceforge.net/projects/pwmscan 上获得。
补充信息
补充数据可在 Bioinformatics 在线获得。
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