Laboratório de Biologia Celular, Departamento de Biologia, Instituto de Biociências, Letras e Ciências Exatas, Universidade Estadual Paulista "Júlio de Mesquita Filho," IBILCE/UNESP, São José do Rio Preto, São Paulo, Brazil.
Departamento de Biologia e Zootecnia, Faculdade de Engenharia de Ilha Solteira, Universidade Estadual Paulista "Júlio de Mesquita Filho," FEIS/UNESP, Ilha Solteira, São Paulo, Brazil.
Am J Trop Med Hyg. 2018 Mar;98(3):653-655. doi: 10.4269/ajtmh.17-0657.
is a protozoan of great importance to public health: it has infected millions of people in the world and is the etiologic agent of Chagas disease, which can cause cardiac and gastrointestinal disorders in patients and may even lead to death. The main vector of transmission of this parasite is triatomine bugs, which have a habit of defecating while feeding on blood and passing the parasite to their own hosts through their feces. Although it has been argued that is not pathogenic for this vector, other studies indicate that the success of the infection depends on several molecules and factors, including the insect's intestinal microbiota, which may experience changes as a result of infection that include decreased fitness. Moreover, the effects of infection depend on the insect species, the parasite strain, and environmental conditions involved. However, the parasite-vector interaction is still underexplored. A deeper understanding of this relationship is an important tool for discovering new approaches to transmission and Chagas disease.
它已经感染了全世界数百万人，是克氏锥虫病的病原体，这种疾病会导致患者心脏和胃肠道紊乱，甚至可能导致死亡。这种寄生虫的主要传播媒介是三锥虫，它们有在吸血时排便的习惯，并通过粪便将寄生虫传给它们自己的宿主。尽管有人认为 对这种媒介没有致病性，但其他研究表明，感染的成功取决于几个分子和因素，包括昆虫的肠道微生物群，感染可能导致其适应性降低。此外，感染的影响取决于昆虫种类、寄生虫株和所涉及的环境条件。然而，寄生虫与媒介的相互作用仍未得到充分探索。更深入地了解这种关系是发现新的方法来控制 和克氏锥虫病传播的重要工具。
