Melo Raíssa de Fátima Pimentel, Guarneri Alessandra Aparecida, Silber Ariel Mariano
Laboratório de Bioquímica de Tryps (LaBTryps), Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil.
Vector Behaviour and Pathogen Interaction Group, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, Brazil.
Front Cell Infect Microbiol. 2020 Feb 21;10:27. doi: 10.3389/fcimb.2020.00027. eCollection 2020.
, a hemoflagellate parasite, is the etiological agent of Chagas disease that affects about 6-7 million people worldwide, mostly in Latin America. The parasite life cycle is complex and alternates between an invertebrate host-Triatominae vector-and a mammalian host. The parasite adaptation to the several microenvironments through which it transits is critical to success in establishing infection. Moreover, environmental cues also play an important role on the parasite development, and it can modulate the infection. In the present study, we discussed how the temperature oscillations and the nutritional state of the invertebrate host can affect the parasite development, multiplication, and the differentiation process of epimastigote forms into metacyclic trypomastigotes, called metacyclogenesis. The impact of oxidative imbalance and osmotic stresses on the parasite-vector relationship are also discussed.
克氏锥虫是一种血液鞭毛虫寄生虫，是恰加斯病的病原体，全球约有600 - 700万人受其影响，主要在拉丁美洲。该寄生虫的生命周期复杂，在无脊椎动物宿主（锥蝽亚科媒介）和哺乳动物宿主之间交替。寄生虫对其经历的多种微环境的适应对于成功建立感染至关重要。此外，环境线索对寄生虫的发育也起着重要作用，并且可以调节感染。在本研究中，我们讨论了温度振荡和无脊椎动物宿主的营养状态如何影响寄生虫的发育、增殖以及前鞭毛体形式向循环后期锥鞭毛虫（称为循环后期发育）的分化过程。还讨论了氧化失衡和渗透应激对寄生虫与媒介关系的影响。
