Black Nicholas, Hamada Hazim
Department of General and Geriatric Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
BMJ Case Rep. 2018 Mar 7;2018:bcr-2017-223484. doi: 10.1136/bcr-2017-223484.
An 80-year-old woman presented with a 5-week history of increasing confusion. Examination was remarkable only for deficits in short-term memory and paranoid thoughts. Blood tests revealed hyponatraemia, and further biochemical testing was consistent with syndrome of inappropriate antidiuretic hormone (SIADH). After an exhaustive diagnostic workup for causes of SIADH, the only abnormal finding was a mildly raised antivoltage-gated potassium channel (VGKC) titre of 185 pmol/L (0-69) consistent with possible anti-VGKC autoimmune limbic encephalitis. However, other diagnostic features were absent. She is currently undergoing outpatient investigation for other causes of memory loss.
一名80岁女性，出现意识混乱加重5周的症状。检查仅发现短期记忆缺陷和偏执观念。血液检查显示低钠血症，进一步的生化检查结果与抗利尿激素分泌异常综合征（SIADH）相符。在对SIADH的病因进行全面诊断检查后，唯一的异常发现是抗电压门控钾通道（VGKC）滴度轻度升高至185 pmol/L（0 - 69），这可能与抗VGKC自身免疫性边缘叶脑炎有关。然而，未发现其他诊断特征。她目前正在门诊接受针对其他失忆原因的检查。
