吡嗪霉素 A 和 B：来自 Lechevalieria aerocolonigenes K10-0216 的新型噻唑基吡啶的结构和生物活性。
Pyrizomicin A and B: structure and bioactivity of new thiazolyl pyridines from Lechevalieria aerocolonigenes K10-0216.
机构信息
Graduate School of Infection Control Sciences, Kitasato University, Tokyo, Japan.
Kitasato Institute for Life Sciences, Kitasato University, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 2018 Jun;71(6):606-608. doi: 10.1038/s41429-018-0038-y. Epub 2018 Mar 7.
Two new antibiotics, designated pyrizomicin A and B, were isolated from the cultured broth of a rare actinomycete strain, Lechevalieria aerocolonigenes K10-0216, by silica gel and HPLC purification. The chemical structures of pyrizomicin A and B were elucidated as new thiazolyl pyridine compounds by nuclear magnetic resonance and mass spectrometry. Pyrizomicin A and B both showed antimicrobial activity.
从稀有放线菌菌株 Lechevalieria aerocolonigenes K10-0216 的发酵液中分离得到两种新的抗生素，分别命名为吡嗪霉素 A 和 B。通过硅胶和 HPLC 纯化得到吡嗪霉素 A 和 B。通过核磁共振和质谱确定吡嗪霉素 A 和 B 的化学结构为新型噻唑基吡啶化合物。吡嗪霉素 A 和 B 均表现出抗菌活性。
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