Newell Johan, Mairesse Olivier, Neu Daniel
Sleep Laboratory and Unit for Chronobiology U78, Brugmann University Hospital, Université Libre de Bruxelles (U.L.B.), Arthur Van Gehuchten Square 4, Building Hh, 1020, Brussels, Belgium.
Department EXTO, Vrije Universiteit Brussel (V.U.B.), Brussels, Belgium.
Sleep Breath. 2018 Dec;22(4):1143-1151. doi: 10.1007/s11325-018-1650-6. Epub 2018 Mar 7.
Until now, there is no clear consensus on optimal care for mild sleep-related breathing disorders (SRBD) in general or for positional obstructive sleep apnea (POSA) in particular. Most proposed treatment options are either invasive and/or expensive. Positional therapy (PT) may therefore present as a valuable first-line intervention in POSA.
Twenty-eight patients presenting with POSA were enrolled in a prospective cohort study. The protocol consisted of three nights of polysomnography (PSG) in an academic sleep lab. Inclusion was based on the first PSG. During a consecutive PSG, PT was provided by means of a sleep-positioning pillow (Posiform®). The third PSG was performed after 1 month of PT. Sleepiness, fatigue, and sleep quality were assessed with the Epworth Sleepiness Scale (ESS), the fatigue severity scale (FSS), the Pittsburgh Sleep Quality Index (PSQI), and the Function Outcomes of Sleep Questionnaire (FOSQ) at baseline, and after 1 and at 6 months of PT alongside satisfaction and compliance ratings.
Significant immediate treatment effects after one night and sustained after 1 month were observed by significant reductions of sleep in supine position (p < .001), sleep fragmentation (p < .05), apnea-hypopnea (p < .001), respiratory disturbance (p < .001), and oxygen desaturation (p < .001) indices. PSQI (p < .001), ESS (p < .005), and FOSQ (p < .001) also showed significant and persistent improvements.
Combined effects on sleep-related respiration and clinical symptoms were observed after PT initiation as well as after 1 month using the sleep-positioning pillow. Furthermore, reported compliance and overall satisfaction appeared to be highly concordant both at 1 month and 6 months follow-up.
迄今为止,对于一般轻度睡眠相关呼吸障碍(SRBD)尤其是体位性阻塞性睡眠呼吸暂停(POSA)的最佳治疗方法尚无明确共识。大多数建议的治疗方案要么具有侵入性,要么费用高昂。因此,体位疗法(PT)可能是POSA一种有价值的一线干预措施。
28例患有POSA的患者被纳入一项前瞻性队列研究。方案包括在学术睡眠实验室进行三晚的多导睡眠图(PSG)检查。纳入基于首次PSG检查结果。在连续的PSG检查期间,通过睡眠定位枕(Posiform®)进行PT。在PT治疗1个月后进行第三次PSG检查。在基线时、PT治疗1个月和6个月后,使用爱泼华嗜睡量表(ESS)、疲劳严重程度量表(FSS)、匹兹堡睡眠质量指数(PSQI)和睡眠问卷功能结果(FOSQ)评估嗜睡、疲劳和睡眠质量,同时评估满意度和依从性评分。
观察到仰卧位睡眠(p<0.001)、睡眠片段化(p<0.05)、呼吸暂停低通气(p<0.001)、呼吸紊乱(p<0.001)和氧饱和度下降(p<0.001)指数在一晚后有显著的即时治疗效果,并在1个月后持续存在。PSQI(p<0.001)、ESS(p<0.005)和FOSQ(p<0.001)也显示出显著且持续的改善。
开始PT治疗后以及使用睡眠定位枕1个月后,观察到对睡眠相关呼吸和临床症状的综合影响。此外,在1个月和6个月随访时,报告的依从性和总体满意度似乎高度一致。